A Retrospective Study of Synthesis, Structure-Activity Relationship and Antimicrobial Activity of 4-Formyl Pyrazole Containing Isoniazid Moiety: A Review

Anupama Chauhan; Ajay Kumar; Anju Goel

doi:10.14233/ajomc.2022.AJOMC-P374

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Abstract

4-Formyl pyrazole is nitrogen containing heterocyclic aromatic molecule containing isoniazid moiety. The molecule is formed by fusion of two heterocyclic ring i.e. pyrazole and isoniazid. The current paper covers a vast range of methods for synthesis of 4-formyl pyrazole containing isoniazid moiety and its derivatives using variety of catalyst, solvent medium and microwave irridation with a goal of achieving a high yield and rapid separation of products. This work describes 4-formyl pyrazole and isoniazid antimicrobial activity as well as their structural-activity relationship. It also includes the mechanism of action of pyrazole and isoniazid and includes the list of current patents linked to various pharmacological activities in previous past years.

Keywords

4-Formyl pyrazole Isoniazid Pharmacological activity Heterocyclic Mechanism of action Pyrazole.n

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Chauhan, A., Kumar, A., & Goel, A. (2022). A Retrospective Study of Synthesis, Structure-Activity Relationship and Antimicrobial Activity of 4-Formyl Pyrazole Containing Isoniazid Moiety: A Review. Asian Journal of Organic & Medicinal Chemistry, 7(1), 11–22. https://doi.org/10.14233/ajomc.2022.AJOMC-P374

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A Retrospective Study of Synthesis, Structure-Activity Relationship and Antimicrobial Activity of 4-Formyl Pyrazole Containing Isoniazid Moiety: A Review

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