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Abstract

In the present paper, the syntheses of some new thiazoles incorporated with pyran moiety using α-bromo ketones and α,α-dibromo ketone are reported and found that both α-bromo ketones and α,α-dibromo ketone are synthetically equivalent. All the new compounds were characterized by spectral and analytical data. In vitro antibacterial activity shows that some of compounds are more potent than standard drugs against specific bacterial strains. All the compounds show fair antifungal activity, however, none of the compounds is more potent than the standard drug.

Keywords

Dehydroacetic acid Hydrazones Thiazoles Antibacterial agents Antifungal agents a-Bromo ketones a,a-Dibromo ketones

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Lohan, P., Kumar, A., K. Aneja, D., & Prakash, O. (2017). Dibromoketone as Synthetic Equivalent to α-Bromoketones: Synthesis of Some New Thiazole as Antimicrobial Agents. Asian Journal of Organic & Medicinal Chemistry, 2(2), 72–77. https://doi.org/10.14233/ajomc.2017.AJOMC-P37
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