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Abstract

A new series of 4-((5-(2-chlorophenyl)-1,3,4-oxadiazol-2-yl)methoxy)-N-(benzylidene derivatives)benzenamine (5a-k) have been synthesized and were screened for their in vitro antibacterial activity against Gram-positive bacteria (Pseudomonas aeruginosa, Streptococcus pyogenes), Gram-negative bacteria (Escherichia coli, Staphylococcus aureus) and antifungal activity (Candida albicans, Aspergillus niger, Aspergillus clavatus). Synthesized compounds were characterized by IR, mass (MS), 1H NMR and 13C NMR spectra. The synthesized compounds 5b, 5c, 5g and 5i showed potency in terms of antimicrobial activity against tested microorganisms.

Keywords

1 3 4-Oxadiazole Schiff base Antimicrobial evaluation MIC.

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Kapadiya, K., Dubal, G., Bhola, Y., & Dholaria, P. (2020). Synthesis and Antimicrobial Evaluation of 1,3,4-Oxadiazole bearing Schiff Base Moiety. Asian Journal of Organic & Medicinal Chemistry, 5(1), 1–5. https://doi.org/10.14233/ajomc.2020.AJOMC-P199
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