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Abstract

A novel series of 3-methoxy/phthalimido-N,N-diethylphenylene diamine linked β-lactam derivatives have been synthesized via Staudinger cycloaddition reaction. Various imines (3a-c) were prepared quantitatively by refluxing aldehydes (1a-c) with easily procurable N,N-diethylphenylene diamine (2). These on reaction with 2-methoxy/phthalimido acetyl chloride in presence of the triethylamine provide corresponding cis- and trans-1-(4'-diethylamino)phenylazetidin-2-ones (4,5). These synthesized β-lactams (4,5) have been characterized by spectroscopic techniques viz. 1H NMR, IR and elemental analysis (CHN).

Keywords

trans- and cis-Azetidin2-ones Cycloaddition b-Lactams N,N-Diethylphenylene diamine

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S. Magtoof, M., Berry, S., S. Bari, S., K. Banik, B., & Bhalla, A. (2017). Facile Synthesis of Novel 3-Methoxy/ Phthalimido-N,N-diethylphenylene Diamine Substituted β-Lactams . Asian Journal of Organic & Medicinal Chemistry, 2(3), 97–101. https://doi.org/10.14233/ajomc.2017.AJOMC-P38
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