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Abstract

The regioselective epoxide ring opening at less substituted carbon atom of epoxide were reported by nucleophiles like heterocyclic amines which gives well known 1,2-difunctionalized amino alcohols. These are present in many synthetic as well as natural products. The ring opening of epoxide is achieved by cleavage with amines in presence of copper(0) as a catalyst. It is observed that the lithium napthalenide reduction of copper(I) produces a highly reactive form of copper(0) that acts as a catalyst for ring opening of epoxides with an amine.

Keywords

Lithium Napthalenide Copper(0) Amino alcohol Biological activity Activity spectra

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S. Devkate, S., S. Burungale, A., S. Pise, A., & D. Jadhav, S. (2019). Active Copper Catalyzed Regioselective Ring Opening of Epoxides by Heterocyclic Amines: An Efficient Protocol for Synthesis of β-Amino Alcohols. Asian Journal of Organic & Medicinal Chemistry, 4(3), 194–199. https://doi.org/10.14233/ajomc.2019.AJOMC-P213
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