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Abstract

The silicotungstic acid catalyzed microwave assisted synthesis of substituted 4H-pyrimido[2,1-b]thiazole and 4H-pyrimido[2,1-b]benzothiazole derivatives was achieved by one-pot multi-component reaction of 2-aminothiazole or 2-aminobenzthiazole, aldehyde and ethyl acetoacetate under solvent-free condition. A simple, rapid and environmental friendly protocol, good yields and easy work-up are some advantages of this protocol. The structures of the synthesized compounds were established by FT-IR, 1H NMR and mass spectral data.

Keywords

Silicotungstic acid Pyrimido[2 1-b]thiazole Microwave Solvent-free Multicomponent.

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S. Rahate, A., A. Shah, N., S. Jadhav, P., T. Sankpal, S., & V. Chavan*, H. (2020). Silicotungstic Acid Catalyzed Microwave Assisted Synthesis of Fused 4H-Pyrimido[2,1-b]thiazoles and 4H-Pyrimido[2,1-b]benzothiazoles under Solvent-Free Conditions. Asian Journal of Organic & Medicinal Chemistry, 5(1), 62–67. https://doi.org/10.14233/ajomc.2020.AJOMC-P236
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