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Abstract

An efficient approach for the formation of biologically important indolo[2,1-b]quinazoline-6,12-diones in good to moderate yields has been accomplished from 2-haloacetophenones and anthranilamides employing I2/DMSO/CuI under aerobic conditions. This tandem process is believed to proceed via iodination of 2-haloacetophenone followed by Kornblum oxidation and copper-catalyzed intramolecular N-arylation. This method adopts five reactions such as α-halogenation, oxidation, condensation, aromatization and heteroaryl coupling in a single step which makes it as an attractive and useful for the synthesis of indolo[2,1-b]quinazoline-6,12-diones.

Keywords

Indolo[2 1-b]quinazoline-6 12-diones N-arylation Oxidative cyclization Kornblum oxidation Quinazolinone.

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Sridevi, B. (2021). One-Pot Synthesis of Indolo[2,1-b]quinazoline-6,12-diones under Aerobic Conditions. Asian Journal of Organic & Medicinal Chemistry, 6(3), 154–160. https://doi.org/10.14233/ajomc.2021.AJOMC-P329
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