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Abstract

The synthesis of β-lactams as azapseudopeptides was carried out in three stages affording reasonable yields. The Schiff base [ethyl 2-{2- (benzylidene)hydrazinyl}acetate] (2) has been prepared from ethyl hydrazinylacetate and benzaldehydes derivatives. Schiff bases led to novel azapseudopeptide derivatives 3 on treatment with chloro acetyl chloride in the presence of triethylamine. Identification of final compounds were confirmed by FT-IR, 1H NMR and 13C NMR data.

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Hydrazinoester Peptidomimitics Pseudopeptides Schiff base Antibacterial activity

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Redouane, C., Bouhaous, M., Naser, A., & Kajima Mulengi, J. (2016). Synthesis of Novel Azapseudopeptide Derivatives and Their Antimicrobial Activities. Asian Journal of Organic & Medicinal Chemistry, 1(1), 33–37. https://doi.org/10.14233/ajomc.2016.AJOMC-P14
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