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Abstract

3-Benzilidene quinolones have been synthesized by Knoevenagel condensation reactions starting from 1-methyl-4-hydroxyquinolinone with substituted aromatic aldehydes. Olefination of N-methyl 4- hydroxy quinolinone have been successfully carried out in aqueous medium under microwave irradiation method. An expeditious reaction was carried out under the microwave irradiation technique with good to excellent yield (92-98 %). The proposed method is environmentally benign, mild and simple protocol for the synthesis of chalcone of 4-hydroxy quinolondione (3a-l). The final products were characterized by 1H NMR, 13C NMR, Mass and elemental analysis as spectral property.

Keywords

Olefination 4-Hydroxyquinolondione Knoevenagel condensation reaction Microwave irradiation

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Jadhav, S., Vaidya, S., Pardeshi, R., & Shinde, B. (2017). Catalyst Free in Aqueous Medium Olefination of 1-Methyl-4-hydroxyquinolinone under Microwave Irradiation Method. Asian Journal of Organic & Medicinal Chemistry, 1(4), 101–105. https://doi.org/10.14233/ajomc.2016.AJOMC-P30
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