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Abstract
Anti-inflammatory activity of Trachyspermum ammi (Linn.) and Dolichos biflorus Linn seed extract has been evaluated using an animal model. Anti-inflammatory activity of the extracts was measured by carrageenan-induced rat paw edema method considering diclofenac 1 mg/kg as standard drug (positive control). This study was carried out using a dose of 200, 400 and 600 mg/kg aqueous and methanol extract of both samples orally and edema volume was measured at 1, 2 and 3 h after incorporation of carrageenan by digital plethysmometer. The investigation supports the traditional use of these seeds as an anti-inflammatory agent as well as the presence of biological active compounds.
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References
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References
P. Mantri and D.T. Witiak, Curr. Med. Chem., 1, 328 (1994).
L.M. Coussens and Z. Werb, Nature, 420, 860 (2002); https://doi.org/10.1038/nature01322.
S.M. Lucas, N.J. Rothwell and R.M. Gibson, Br. J. Pharmacol., 147(S1), S232 (2006); https://doi.org/10.1038/sj.bjp.0706400.
S.A. Dahanukar, R.A. Kulkarni and N.N. Rege, Indian J. Pharmacol., 32, S81 (2000).
M. Gupta, U. Mazumder, P. Gomathi and V.T. Selvan, BMC Complement. Altern. Med., 6, 36 (2006); https://doi.org/10.1186/1472-6882-6-36.
T. Eisner, eds.: F.H. Borman and S.R. Kellert, Chemical Prospecting: A Proposal for Action, In: Ecology, Economics, Ethics: The Broken Circle, Yale University Press, New Haven CT, pp. 196-202 (1990).
E. Elisabetsky, T.A. Amador, R.R. Albuquerque, D.S. Nunes and A.C.T. Carvalho, J. Ethnopharmacol., 48, 77 (1995); https://doi.org/10.1016/0378-8741(95)01287-N.
N.R. Farnsworth, ed.: E.O.Wilson, Biodiversity, Part II, National Academy Press, Washington, pp. 83-97 (1989).
P.E. Lipsky, Am. J. Med., 106, 51S (1999); https://doi.org/10.1016/S0002-9343(99)00117-5.
W.L. Smith and D.L. De Witt, Semin. Nephrol., 15, 179 (1995).
U. Weiss, Nature, 454, 427 (2008); https://doi.org/10.1038/454427a.
Y. Vodovotz, M. Csete, J. Bartels, S. Chang and G. An, PLOS Comput. Biol., 4, e1000014 (2008); https://doi.org/10.1371/journal.pcbi.1000014.
H.N. Aswatha Ram, N.K. Sriwastava, I.K. Makhija and C.S. Shreedhara, J. Ayurveda Integr. Med., 3, 33 (2012); https://doi.org/10.4103/0975-9476.93946.
T.S. Garimella, C.I. Jolly and S. Narayanan, Phytother. Res., 15, 351 (2001); https://doi.org/10.1002/ptr.833.
S. Laskar, U.K. Bhattarcharyya, A. Sinhababu and B.K. Basak, Fitoterapia, 69, 401 (1998).
A.K. Muthu, S. Sethupathy, R. Manavalan and P.K. Karar, Indian J. Exp. Biol., 43, 522 (2005).
C.A. Winter, E.A. Risley and W. Nuss, Proc. Soc. Exp. Biol. Med., 111, 544 (1962); https://doi.org/10.3181/00379727-111-27849.
M.C. Pant, I. Uddin and U.R. Bhardwaj, Indian J. Med. Res., 56, 1808 (1968).
R.R. Brooks, J.F. Carpenter, S.M. Jones, T.C. Ziegler and S.F. Pong, J. Pharmacol. Methods, 25, 275 (1991); https://doi.org/10.1016/0160-5402(91)90027-3.
S. Basu and J. Ganguly, Asian J. Org. Med. Chem., 1, 17 (2016); https://doi.org/10.14233/ajomc.2016.AJOMC-P9.
M.B. Gupta, T.N. Bhalla, G.P. Gupta, C.R. Mitra and K.P. Bhargava, Eur. J. Pharmacol., 6, 67 (1969); https://doi.org/10.1016/0014-2999(69)90067-3.