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Abstract
In this research work, the composition of polyurethane, titanium di oxide and hydroxyapatite were optimized to obtain a stable polymer nanocomposite microfilm with excellent flexibility and durability, through simple sol-gel synthetic method. The obtained films were further cut by nesting and formed to obtain a flawless stent structure with desirable mechanical, biocompatibility and drug delivery properties. XRD, FTIR, SEM characterizations were performed to study their physical, chemical and biocompatible properties. The tensometer tests, simulated body fluid tests and blood interaction tests showed competitive results that match the properties of conventional materials such as metals and alloys.
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References
- J. Lévesque, D. Dubé, M. Fiset and D. Mantovani, Materials and Properties for Coronary Stents, Adv. Mater. Process., 162, 45 (2004).
- E. Nikolsky, L. Gruberg, S. Pechersky, M. Kapeliovich, E. Grenadier, S. Amikam, M. Boulos, M. Suleiman, W. Markiewicz and R. Beyar, Stent Deployment Failure: Reasons, Implications and Short- and Long-Term Outcomes, Catheter. Cardiovasc. Interv., 59, 324 (2003); https://doi.org/10.1002/ccd.10543.
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- T.G. Papaioannou and C. Stefanadis, Vascular Wall Shear Stress: Basic Principles and Methods, Hellenic J. Cardiol., 46, 9 (2005).
- N. Bruder, Anesth. Analg., 95, 301 (2003).
- J. Krishnamoorthy, Ph.D. Thesis, Studies on Polyurethane Adhesives and Surface Modification of Hydrophobic Substrates, University of Massachusetts Amherst (2014).
- Z. Ma, Y. Hong, D.M. Nelson, J.E. Pichamuthu, C.E. Leeson and W.R. Wagner, Biodegradable Polyurethane Ureas with Variable Polyester or Polycarbonate Soft Segments: Effects of Crystallinity, Molecular Weight and Composition on Mechanical Properties, Biomacromolecules, 12, 3265 (2011); https://doi.org/10.1021/bm2007218.
- J. Guan, K.L. Fujimoto, M.S. Sacks and W.R. Wagner, Preparation and Characterization of Highly Porous, Biodegradable Polyurethane Scaffolds for Soft Tissue Applications, Biomaterials, 26, 3961 (2005); https://doi.org/10.1016/j.biomaterials.2004.10.018.
References
J. Lévesque, D. Dubé, M. Fiset and D. Mantovani, Materials and Properties for Coronary Stents, Adv. Mater. Process., 162, 45 (2004).
E. Nikolsky, L. Gruberg, S. Pechersky, M. Kapeliovich, E. Grenadier, S. Amikam, M. Boulos, M. Suleiman, W. Markiewicz and R. Beyar, Stent Deployment Failure: Reasons, Implications and Short- and Long-Term Outcomes, Catheter. Cardiovasc. Interv., 59, 324 (2003); https://doi.org/10.1002/ccd.10543.
G. Maluenda, I. Ben-Dor, M.A. Gaglia, K. Wakabayashi, M. Mahmoudi, G. Sardi, A. Laynez-Carnicero, R. Torguson, Z. Xue, A.D. Margulies, W.O. Suddath, K.M. Kent, N.L. Bernardo, L.F. Satler, A.D. Pichard and R. Waksman, Clinical Outcomes and Treatment After Drug-Eluting Stent Failure: The Absence of Traditional Risk Factors for In-Stent Restenosis, Circ. Cardiovasc. Interv., 5, 12 (2012); https://doi.org/10.1161/CIRCINTERVENTIONS.111.963215.
T.G. Papaioannou and C. Stefanadis, Vascular Wall Shear Stress: Basic Principles and Methods, Hellenic J. Cardiol., 46, 9 (2005).
N. Bruder, Anesth. Analg., 95, 301 (2003).
J. Krishnamoorthy, Ph.D. Thesis, Studies on Polyurethane Adhesives and Surface Modification of Hydrophobic Substrates, University of Massachusetts Amherst (2014).
Z. Ma, Y. Hong, D.M. Nelson, J.E. Pichamuthu, C.E. Leeson and W.R. Wagner, Biodegradable Polyurethane Ureas with Variable Polyester or Polycarbonate Soft Segments: Effects of Crystallinity, Molecular Weight and Composition on Mechanical Properties, Biomacromolecules, 12, 3265 (2011); https://doi.org/10.1021/bm2007218.
J. Guan, K.L. Fujimoto, M.S. Sacks and W.R. Wagner, Preparation and Characterization of Highly Porous, Biodegradable Polyurethane Scaffolds for Soft Tissue Applications, Biomaterials, 26, 3961 (2005); https://doi.org/10.1016/j.biomaterials.2004.10.018.