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Abstract
A series of ortho and para substituted 1-[benzothiazol-(1H)-2-yl]-3- phenyl-prop-2-en-1-one derivatives were synthesized from 2-acetyl benzothiazole and ortho and para-substituted benzaldehye using ethanol as solvent. The synthesized compounds were characterized by UVvisible, FT-IR, 1H NMR and mass spectrometry. Antioxidant activities of synthesized compounds have been evaluated by DPPH free radical scavenging activity using ascorbic acid as standard. The standard solution and 1-[benzothiazol-(1H)-2-yl]-3-phenylprop-2-en-1-ones compounds were prepared with different concentrations. Anticancer activity of 1-[benzothiazol-(1H)-2-yl]-3-phenylprop-2-en-1-one and 1-[benzothiazol-(1H)-2-yl]-3(4-chlorophenyl)prop-2-en-1-one were assigned by MTT assays.
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References
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References
B.T. Yin, C.Y. Yan, X.-M. Peng, S.-L. Zhang, S. Rasheed, R.-X. Geng and C.-H. Zhou, Synthesis and Biological Evaluation of a-Triazolyl Chalcones as a New Type of Potential Antimicrobial Agents and their Interaction with Calf Thymus DNA and Human Serum Albumin, Eur. J. Med. Chem., 71, 148 (2014); https://doi.org/10.1016/j.ejmech.2013.11.003.
C. Dyrager, M. Wickström, M. Fridén-Saxin, A. Friberg, K. Dahlén, E.A.A. Wallén, J. Gullbo, M. Grøtli and K. Luthman, Inhibitors and Promoters of Tubulin Polymerization: Synthesis and Biological Evaluation of Chalcones and Related Dienones as Potential Anticancer Agents, Bioorg. Med. Chem., 19, 2659 (2011); https://doi.org/10.1016/j.bmc.2011.03.005.
K.V. Sashidhara, S.R. Avula and G.R. Palnati, S.V. Singh, K. Srivastava, S.K. Puri and J.K. Saxena, Synthesis and in vitro Evaluation of New Chloroquine-Chalcone Hybrids Against Chloroquine-Resistant Strain of Plasmodium falciparum, Bioorg. Med. Chem. Lett., 22, 5455 (2012); https://doi.org/10.1016/j.bmcl.2012.07.028.
T. Narsinghani, M.C. Sharma and S. Bhargav, Synthesis, Docking Studies and Antioxidant Activity of Some Chalcone and Aurone Derivatives, Med. Chem. Res., 22, 4059 (2013); https://doi.org/10.1007/s00044-012-0413-3.
C. Jin, Y.J. Liang, H. He and L. Fu, Synthesis and Antitumor Activity of Novel Chalcone Derivatives, Biomed. Pharmacother., 67, 215 (2013); https://doi.org/10.1016/j.biopha.2010.12.010.
K.V. Sashidhara, M. Kumar, R.K. Modukuri, R. Sonkar, G. Bhatia, A.K. Khanna, S. Rai and R. Shukla, Synthesis and Anti-Inflammatory Activity of Novel Biscoumarin-Chalcone Hybrids, Bioorg. Med. Chem. Lett., 21, 4480 (2011); https://doi.org/10.1016/j.bmcl.2011.06.002.
X. Sui, Y.C. Quan, Y. Chang, R.-P. Zhang, Y.-F. Xu and L.-P. Guan, Synthesis and Studies on Antidepressant Activity of 2¢,4¢,6¢-Trihydroxy-chalcone Derivatives, Med. Chem. Res., 21, 1290 (2012); https://doi.org/10.1007/s00044-011-9640-2.
P. Janaki, K.G. Sekar and G. Thirunarayanan, Synthesis, Spectral Corre-lation and Insect Antifeedant Activities of Some 2-Benzimidazole Chalcones, J. Saudi Chem. Soc., 20, 58 (2016); https://doi.org/10.1016/j.jscs.2012.11.013.
S. De, S. Adhikari, J. Tilak-Jain, V.P. Menon and T.P. Devasagayam, Antioxidant Activity of an Aminothiazole Compound: Possible Mechan-isms, Chem. Biol. Interact., 17, 215 (2008); https://doi.org/10.1016/j.cbi.2008.03.011.
A. Mohammad, F.B. Faruqi and J. Mustafa, Synthesis, Spectroscopic and in vitro Cytotoxic Studies of Fatty Acid Analogues of 2,6-Diisopropyl-phenol, J. Cancer Ther., 1, 124 (2010); https://doi.org/10.4236/jct.2010.13020.