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Abstract

A series of ortho and para substituted 1-[benzothiazol-(1H)-2-yl]-3- phenyl-prop-2-en-1-one derivatives were synthesized from 2-acetyl benzothiazole and ortho and para-substituted benzaldehye using ethanol as solvent. The synthesized compounds were characterized by UVvisible, FT-IR, 1H NMR and mass spectrometry. Antioxidant activities of synthesized compounds have been evaluated by DPPH free radical scavenging activity using ascorbic acid as standard. The standard solution and 1-[benzothiazol-(1H)-2-yl]-3-phenylprop-2-en-1-ones compounds were prepared with different concentrations. Anticancer activity of 1-[benzothiazol-(1H)-2-yl]-3-phenylprop-2-en-1-one and 1-[benzothiazol-(1H)-2-yl]-3(4-chlorophenyl)prop-2-en-1-one were assigned by MTT assays.

Keywords

Benzothiazoles DPPH Free radical Antioxidant acitivity Anticancer activity

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How to Cite
Anuba, C., & Abbs Fen Reji, T. (2019). Synthesis, Characterization and Biological Activities of Substituted 1-[Benzothiazol-(1H)- 2-yl]-3-phenyl-prop-2-en-1-ones. Asian Journal of Organic & Medicinal Chemistry, 4(3), 144–146. https://doi.org/10.14233/ajomc.2019.AJOMC-P181
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