Article Sidebar

Download
PDF

Main Article Content

Abstract

In this research study, iron nanoparticles (FeNPs) were synthesized using Gymnema sylvestre (Asclepiadaceae) leaves extract. Iron(III) ions present in ammonium ferrous sulphate hexahydrate were reduced to FeNPs by phytoconstituents in Gymnema sylvestre leaves extract. The characteristics of biosynthesized FeNPs were studied by using UV-visible absorption spectroscopy (UV-vis), transmission electron microscopy (TEM), particle size analyzer (PSA) and Fourier transform infrared spectroscopy (FTIR). The typical absorption peak was found to lie within 650-700 nm due to the excitation of surface plasmon vibration in FeNPs. The spherical structures of FeNPs were found in the range of 8-40 nm with average particle size of 405.8 nm. The antibacterial study of the biosynthesized FeNPs was performed against Gram-positive (B. subtilis) bacteria and Gram-negative (E. coli) bacteria by the agar well dispersion technique. The zone of inhibition of antibacterial activity of FeNPs against B. subtilis and E. coli bacteria was found to be 27.5 and 29 mm, respectively.

Keywords

Nanotechnology Iron nanoparticles Gymnema sylvestre.

Article Details

License

Copyright (c) 2022 Asian Journal of Organic & Medicinal Chemistry

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

How to Cite
Kumari, S., Sheoran, P., Jangra, S., & Tiwari, V. (2023). Application of Gymnema sylvestre Leaves Extract for Iron Nanoparticles Synthesis and Antibacterial Activity Evaluation. Asian Journal of Organic & Medicinal Chemistry, 7(4), 299–303. https://doi.org/10.14233/ajomc.2022.AJOMC-P406
Download Citation
Endnote/Zotero/Mendeley (RIS)
BibTeX

References

  1. I. Khan, K. Saeed and I. Khan, Nanoparticles: Properties, Applications and Toxicities, Arabian J. Chem., 12, 908 (2019); https://doi.org/10.1016/j.arabjc.2017.05.011
  2. J. Jeevanandam, A. Barhoum, Y.S. Chan, A. Dufresne and M.K. Danquah, Review on Nanoparticles and Nanostructured Materials: History, Sources, Toxicity and Regulations, Beilstein J. Nanotechnol., 9, 1050 (2018); https://doi.org/10.3762/bjnano.9.98
  3. A. Schröfel, G. Kratošová, I. Šafarík, M. Šafaríková, I. Raška and L.M. Shor, Applications of Biosynthesized Metallic Nanoparticles-A Review, Acta Biomater., 10, 4023 (2014); https://doi.org/10.1016/j.actbio.2014.05.022
  4. B.I. Kharisov, H.V. Rasika-Dias, O.V. Kharissova, V. Manuel Jiménez-Pérez, B. Olvera-Pérez and B. Muñoz-Flores, Iron-Containing Nanomaterials: Synthesis, Properties and Environmental Applications, RSC Adv., 2, 9325 (2012); https://doi.org/10.1039/c2ra20812a
  5. A. Hassanjani-Roshan, M.R. Vaezi, A. Shokuhfar and Z. Rajabali, Synthesis of Iron Oxide Nanoparticles via Sonochemical Method and their Characterization, Particuology, 9, 95 (2011); https://doi.org/10.1016/j.partic.2010.05.013
  6. S. Ge, X. Shi, K. Sun, C. Li, C. Uher, J.R. Baker Jr., M.M. Banaszak Holl and B.G. Orr, Facile Hydrothermal Synthesis of Iron Oxide Nanoparticles with Tunable Magnetic Properties, J. Phys. Chem. C, 113, 13593 (2009); https://doi.org/10.1021/jp902953t
  7. R. Ray, S. Das, M. Patra and M. Thakur, Iron Nanoparticles from an Electrochemical Route, Nanosci. Methods, 1, 1 (2012); https://doi.org/10.1080/17458080.2010.517570
  8. M. Salvador, G. Gutiérrez, S. Noriega, A. Moyano,M.C. Blanco-López and M. Matos, Microemulsion Synthesis of Superparamagnetic Nanoparticles for Bioapplications, Int. J. Mol. Sci., 22, 427 (2021); https://doi.org/10.3390/ijms22010427
  9. P.L. Hariani, M. Faizal, M. Ridwan and D. Setiabudidaya, Synthesis and Properties of Fe3O4 Nanoparticles by Co-Precipitation Method to Removal Procion Dye, Int. J. Environ. Sci. Dev., 4, 336 (2013); https://doi.org/10.7763/IJESD.2013.V4.366
  10. A. Ali, H. Zafar, M. Zia, I. ul Haq, A.R. Phull, J.S. Ali and A. Hussain, Synthesis, Characterization, Applications, and Challenges of Iron Oxide Nanoparticles, Nanotechnol. Sci. Appl., 9, 49 (2016); https://doi.org/10.2147/NSA.S99986
  11. S. Saranya, K. Vijayarani and S. Pavithra, Green Synthesis of Iron Nanoparticles using Aqueous Extract of Musa ornata Flower Sheath against Pathogenic Bacteria, Indian J. Pharm. Sci., 79, 688 (2017); https://doi.org/10.4172/pharmaceutical-sciences.1000280
  12. K.S.V. Gottimukkala, P. Harika Reddy and D. Zamare, Green Synthesis of Iron Nanoparticles Using Green Tea leaves Extract, J. Nanomed. Biotherap. Discov., 7, 151 (2017); https://doi.org/10.4172/2155-983X.1000151
  13. Priya, Naveen, K. Kaur and A.K. Sidhu, Green Synthesis: An Eco-Friendly Route for the Synthesis of Iron Oxide Nanoparticles, Front. Nanotechnol., 3, 655062 (2019); https://doi.org/10.3389/fnano.2021.655062
  14. H. Chopra, S. Bibi, I. Singh, M.M. Hasan, M.S. Khan, Q. Yousafi, A.A. Baig, M.M. Rahman, F. Islam, T.B. Emran and S. Cavalu, Front. Bioeng. Biotechnol., 10, 874742 (2022); https://doi.org/10.3389/fbioe.2022.874742
  15. C.A. De León-Condés, G. Roa-Morales, G. Martínez-Barrera, P. Balderas-Hernández, C. Menchaca-Campos and F. Ureña-Núñez, A Novel Sulfonated Waste Polystyrene/Iron Oxide Nanoparticles Composite: Green Synthesis, Characterization and Applications, J. Environ. Chem. Eng., 7, 102841 (2019); https://doi.org/10.1016/j.jece.2018.102841
  16. G.B. Jegadeesan, K. Srimathi, N.S. Srinivas, S. Manishkanna and D. Vignesh, Green Synthesis of Iron Oxide Nanoparticles using Terminalia bellirica and Moringa oleifera fruit and Leaf Extracts: Antioxidant, Antibacterial and Thermoacoustic Properties, Biocatal. Agric. Biotechnol., 21, 101354 (2019); https://doi.org/10.1016/j.bcab.2019.101354
  17. F. Khan, M.M.R. Sarker, L.C. Ming, I.N. Mohamed, C. Zhao, B.Y. Sheikh, H.F. Tsong and M.A. Rashid, Comprehensive Review on Phyto-chemicals, Pharmacological and Clinical Potentials of Gymnema sylvestre, Front. Pharmacol., 10, 1223 (2019); https://doi.org/10.3389/fphar.2019.01223
  18. B. Chodisetti, K. Rao and A. Giri, Phytochemical Analysis of Gymnema Sylvestre and Evaluation of its Antimicrobial Activity, Nat. Prod. Res., 27, 583 (2013); https://doi.org/10.1080/14786419.2012.676548
  19. G. Di Fabio, V. Romanucci, M. Zarrelli, M. Giordano and A. Zarrelli, C-4 Gem-Dimethylated Oleanes of Gymnema sylvestre and their Pharmacological Activities, Molecules, 18, 14892 (2013) https://doi.org/10.3390/molecules181214892
  20. A.A.M. El Shafey, M.M. El-Ezabi, M.M.E. Seliem, H.H.M. Ouda and D.S. Ibrahim, Effect of Gymnema sylvestre R. Br. Leaves Extract on Certain Physiological Parameters of Diabetic Rats, J. King Saud Univ. Sci., 25, 135 (2013); https://doi.org/10.1016/j.jksus.2012.11.001
  21. K. Arunachalam, L.B. Arun, S.K. Annamalai and A.M. Arunachalam, Potential Anticancer Properties of Bioactive Compounds of Gymnema sylvestre and its Biofunctionalized Silver Nanoparticles, Int. J. Nanomedicine, 31, 31 (2014); https://doi.org/10.2147/IJN.S71182
  22. G.D. Fabio, V. Romanucci, A.D. Marco and A. Zarrelli, Triterpenoids from Gymnema sylvestre and their Pharmacological Activities, Molecules, 19, 10956 (2014); https://doi.org/10.3390/molecules190810956
  23. D.K. Singh, N. Kumar, A. Sachan, P. Lakhani, S. Tutu, R. Nath, A.K. Sachan and R.K. Dixit, Hypolipidaemic Effects of Gymnema sylvestre on High Fat Diet Induced Dyslipidaemia in Wistar Rats, J. Clin. Diagnostic Res., 11, FF01 (2017); https://doi.org/10.7860/JCDR/2017/27430.9859
  24. M. Thanwar, D. Dwivedi, A.K. Gharia and S. Chouhan, Antibacterial study of Gymnema sylvestre plant, Int. J. Chem. Stud., 4, 80 (2016).
  25. B.C. David and G. Sudarsanam, Antimicrobial Activity of Gymnema sylvestre (Asclepiadaceae), J. Acute Dis., 2, 222 (2013); https://doi.org/10.1016/S2221-6189(13)60131-6
  26. J.K. Malik, F.V. Manvi, K.R. Alagawadi and M. Noolvi, Evaluation of Anti-inflammatory Activity of Gymnema sylvestre Leaves Extract in Rats, Int. J. Green Pharmacy, 2, 114 (2008).
  27. P. Tiwari, B.N. Mishra and N.S. Sangwan, Phytochemical and Pharma-cological Properties of Gymnema sylvestre: An Important Medicinal Plant, BioMed Res. Int., 2014, 830285 (2014); https://doi.org/10.1155/2014/830285
  28. B. Turakhia, P. Turakhia and S.P. Shah, Green Synthesis of Zero Valent Iron Nanoparticles from Spinacia oleracea (spinach) and Its Application in Waste Water Treatment, J. Adv. Res. Appl. Sci., 5, 46 (2018).
  29. M. Pattanayak and P.L. Nayak, Green Synthesis and Characterization of Zero Valent Iron Nanoparticles from the Leaf Extract of Azadirachta indica (Neem), World J. Nano Sci. Technol., 2, 6 (2013); https://doi.org/10.5829/idosi.wjnst.2013.2.1.21132
  30. K.M. Kumar, B.K. Mandal, K.S. Kumar, P.S. Reddy and B. Sreedhar, Biobased Green Method to Synthesize Palladium and Iron Nanoparticles using Terminalia chebula Aqueous Extract, Spectrochim. Acta A Mol. Biomol. Spectrosc., 102, 128 (2013); https://doi.org/10.1016/j.saa.2012.10.015
  31. R. Herrera-Becerra, J.L. Rius and C. Zorrilla, Tannin Biosynthesis of Iron Oxide Nanoparticles, Appl. Phys. A, 100, 453 (2010); https://doi.org/10.1007/s00339-010-5903-x
  32. Y. Wei, Z. Fang, L. Zheng, L. Tan and E.P. Tsang, Green Synthesis of Fe Nanoparticles using Citrus maxima Peels Aqueous Extracts, Mater. Lett., 185, 384 (2016); https://doi.org/10.1016/j.matlet.2016.09.029
  33. A.S.Y. Ting and J.E. Chin, Biogenic Synthesis of Iron Nanoparticles from Apple Peel Extracts for Decolorization of Malachite Green Dye, Water Air Soil Pollut., 231, 278 (2020); https://doi.org/10.1007/s11270-020-04658-z
  34. A. Ebrahiminezhad, A. Zare-Hoseinabadi, A. Berenjian and Y. Ghasemi, Green synthesis and Characterization of Zero-valent Iron Nanoparticles using Stinging Nettle (Urtica dioica) Leaf Extract, Green Process. Synthesis., 6, 469 (2017); https://doi.org/10.1515/gps-2016-0133