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Abstract

A series of novel 2-aminothiazole derivatives were synthesized by microwave assisted method as a green chemistry approach and characterized by spectral techniques and elemental analysis. The antioxidant potential of the derivatives was determined by using molecular docking against two different oxidoreductase protein (PDB: 2CDU and 3NM8). Compounds 3a and 3d show the stronger binding affinity to the target protein. The synthesized drug was pharmacologically evaluated for the antioxidant activity using ascorbic acid as a reference drug, where compound 3a showed the highest inhibition.

Keywords

Thiazole Microwave assisted synthesis Antioxidant in silico activity Molecular docking.

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Copyright (c) 2022 Asian Journal of Organic & Medicinal Chemistry

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R. Mali, D., Popat Ghuhe, A., Murlidhar Khairnar, N., & Milind Kothawade, S. (2023). In silico Study, Molecular Docking and Synthesis of 2-Amino thiazole Derivatives using Green Chemistry Approach as Antioxidant Agent. Asian Journal of Organic & Medicinal Chemistry, 7(4), 280–286. https://doi.org/10.14233/ajomc.2022.AJOMC-P402
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