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Abstract

Benzodiazepine-2-one moiety consists of a seven-membered heterocyclic ring, a derivative of benzodiazepine group, that works in the central nervous system and used for a variety of medical conditions, such as anxiety, seizures and alcohol withdrawal. Microwave assisted synthesis of certain medically important benzodiazepin-2-ones was carried out using hexamine and ammonium chloride starting from 2-aminobenzophenones. Feasibility and optimization of the reaction conditions under closed vessel CEM microwave synthesizer provide the desired product with excellent yields (~90%), within minutes of focused microwave irradiation, without the use of catalyst, thereby, revealing the benefit of saving energy and time.

Keywords

Microwave synthesizer Cyclization Hexamine Ammonium chloride Benzodiazepin-2-one Microwave irradiation.

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K. Khatri, J., R. Pednekar, S., & S. Chaughule, R. (2022). Energy Efficient Synthesis of various Benzodiazepin-2-ones using Microwave Synthesizer. Asian Journal of Organic & Medicinal Chemistry, 7(3), 235–238. https://doi.org/10.14233/ajomc.2022.AJOMC-P396
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