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Abstract

1,3-Dipolar cycloaddition of in situ generated non-stabilized azomethine ylides through the decarboxylative condensation of sarcosine and substituted isatins with 2-(arylmethylene)-2,3-dihydro-1H-inden-1-ones in microwave produced dispiro[1H-indene-2,3′-pyrrolidine-2′,3′′-[3H]indole]-1,2′′(1′′H)diones in a highly stereo- and regio-selective fashion. The synthesized compounds were subjected to antibacterial and antifungal studies. It was found that many compounds possess a considerable antibacterial and antifungal activity against all the tested organisms.

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1 3-Dipolar cycloaddition Azomethine Ylides Dispiro compounds Antibacterial activity Antifungal activity.

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Kaleeswari, M., & Harikrishnan, P. (2022). Microwave Assisted a Highly Atom Economic, Chemo-, Regio- and Stereoselective Synthesis and Evaluation of Dispiro[1H-indene-2,3′-pyrrolidine-2′,3′′-[3H]indole]-1,2′′(1′′H)diones as Antibacterial and Antifungal Agents. Asian Journal of Organic & Medicinal Chemistry, 7(1), 23–30. https://doi.org/10.14233/ajomc.2022.AJOMC-P356
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