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Abstract

Several new substituted thiadiazole pyrazolene anthranilic acid derivatives were synthesized. These compounds also evaluated for their anti-inflammatory and analgesic activities. Compound 2-((5-(3-(2,6-dichloro)acrylamido)-1,3,4-thiadiazol-2-yl)methyl amino)-benzoic acid (5b) and 2-((5-(1-acetyl-5-(2,6-dichloro)-4,5-dihydro-1H-pyrazol-3-ylamino)-1,3,4-thiadiazol-2-yl)methyl amino)benzoic acid (6b) were found to be most active compounds of this series, which exhibits 38.10 & 48.50% anti-inflammatory activity while, 36.24 & 40.10 % analgesic activity, respectively. The structures of all the compounds were characterized by analytical data, IR, 1H NMR and mass spectrometry.

Keywords

Thiadiazoles Pyrazolene Anthranilic acid derivatives Analgesic activity Anti-inflammatory activity.

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Kumar, D. (2022). Synthesis and Characterization of Thiadiazole Pyrazolene Anthranilic Acid Derivatives as Potent Anti-inflammatory Agents. Asian Journal of Organic & Medicinal Chemistry, 7(1), 84–91. https://doi.org/10.14233/ajomc.2022.AJOMC-P366
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