Main Article Content
Abstract
A novel route for the synthesis of chalcone derivatives by using Claisen-Schmidt condensation between substituted acetophenones
and substituted aromatic aldehyde in the presence of aqueous solution of KOH and ethyl alcohol at room temperature. The synthesized
compound were analyzed by IR and 1H spectral data. All compounds were evaluated for their antibacterial and antifungal activities by cupplate method.
Keywords
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References
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References
Y. Rajendraprasad, A. Lakshmana Rao and R. Rambabu, Synthesis and Antimicrobial Activity of Some Chalcone Derivatives, E-J. Chem.,
, 461 (2008); https://doi.org/10.1155/2008/876257
S.N. López, M.V. Castelli, S.A. Zacchino, J.N. Domínguez, G. Lobo, J. Charris-Charris, J.C.G. Cortés, J.C. Ribas, C. Devia, A.M. Rodríguez and R.D. Enriz, Bioorg. Med. Chem., 9, 1999 (2001); https://doi.org/10.1016/s0968-0896(01)00116-x
B. Baviskar, S. Patel, B. Baviskar, S.S. Khadabadi and M. Shiradkar, Design and Synthesis of Some Novel Chalcones as Potent Antimicrobial Agent, Asian J. Res. Chem., 1, 67 (2008).
F. Herencia, M. Luisa-Ferrandiz, A. Ubeda, N. Domínguez, J.E. Charris, G.M. Lobo and M. Jose-Alcaraz, Synthesis and Anti-inflammatory Activity of Chalcone Derivatives, Bioorg. Med. Chem. Lett., 8, 1169 (1998); https://doi.org/10.1016/S0960-894X(98)00179-6
X. Wu, P. Wilairat and M.-L. Go, Antimalarial Activity of Ferrocenyl Chalcones, Bioorg. Med. Chem. Lett., 12, 2299 (2002); https://doi.org/10.1016/S0960-894X(02)00430-4
T. Narender, T. Khaliq, Shweta, Nishi, N. Goyal and S. Gupta, Synthesis of Chromenochalcones and Evaluation of their in vitro Antileishmanial Activity, Bioorg. Med. Chem., 13, 6543 (2005); https://doi.org/10.1016/j.bmc.2005.07.005
J.-H. Cheng, C.-F. Hung, S.-C. Yang, J.-P. Wang, S.-J. Won and C.-N. Lin, Synthesis and Cytotoxic, Anti-Inflammatory and Anti-Oxidant Activities of 2′,5′-Dialkoxylchalcones as Cancer Chemopreventive Agents, Bioorg. Med. Chem., 16, 7270 (2008); https://doi.org/10.1016/j.bmc.2008.06.031
Y.-M. Lin, Y. Zhou, M.T. Flavin, L.-M. Zhou, W. Nie and F.-C. Chen, Bioorg. Med. Chem., 10, 2795 (2002); https://doi.org/10.1016/S0968-0896(02)00094-9
P.M. Sivakumar, S.P. Seenivasan, V. Kumar and M. Doble, Synthesis, Antimycobacterial Activity Evaluation and QSAR Studies of Chalcone Derivatives, Bioorg. Med. Chem. Lett., 17, 1695 (2007); https://doi.org/10.1016/j.bmcl.2006.12.112
P.G. Kumdale and N.V. Shitole, Synthesis of Pyrazole Compounds by Using Sonication Method, Orient. J. Chem., 38, 198 (2022); https://doi.org/10.13005/ojc/380125
D. Gupta and D.K. Jain, Chalcone Derivatives as Potential Antifungal Agents: Synthesis and Antifungal Activity, J. Adv. Pharm. Technol. Res., 6, 114 (2015); https://doi.org/10.4103/2231-4040.161507
S. Saisivam and V.B. Kishan, Standard Method of Antifungal Activity, Indian J. Microbiol., 46, 13 (2006).
S.J. Wadher, A.R. Tapas and P.G. Yeole, Studies on Synthesis and Antioxidant Activity of Some New Flavones, Int. J. Chem. Sci., 4, 761 (2006).
A.R. Tapas, D.M. Sakarkar and R.B. Kakde, Flavonoids as Nutraceuticals: A Review, Tropical J. Pharm. Res., 7, 1089 (2008); https://doi.org/10.4314/tjpr.v7i3.14693
A.R. Tapas, D.M. Sakarkar and R.B. Kakde, The Chemistry and Biology of Bioflavonoids, Res. J. Pharm. Tech., 1, 132 (2008).