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012-AJOMC P409 (322-326)

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Abstract

A sustainable, multi-component reaction has been established for the synthesis of pyranopyrazole in an aqueous medium utilizing  Cu(OTf)2 as catalyst. This eco-friendly synthesis process utilizes aromatic aldehydes, malonitrile, hydrazine hydrate and ethyl  acetoacetate as substrates to obtain pyranopyrazole derivatives. The method is characterized by its mild reaction conditions, cost- effectiveness, high efficiency, energy savings and functional group tolerance, producing the target compounds in good to excellent  yields. Copper(II) triflate [Cu(OTf)2] demonstrates high catalytic efficacy without generating side products and can be easily recovered  post-reaction without complex procedures. The structure of the synthesized pyranopyrazole derivatives were confirmed using  spectroscopic analysis. 

Keywords

Pyranopyrazoles Copper(II) triflate Aromatic aldehyde Malonitrile Ethyl acetoacetate Hydrazine hydrate

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Asatkar, A., & Pahare, S. (2021). A Green and Efficient Sythesis of Pyranopyrazole Derivatives Catalyzed by Copper(II) triflate in Aqueous Medium. Asian Journal of Organic & Medicinal Chemistry, 6(4), 322–326. Retrieved from https://asianpubs.org/index.php/ajomc/article/view/33219
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