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Abstract
A novel series of 2,4,6-trisubstituted 1,4-dihydropyridine derivatives was designed and utilized for the computational studies for predicting absorption, distribution metabolism, elimination (ADME), pharmacological profile, toxicity and molecular docking of these derivatives. Some of the derivatives were found to have significant antihypertensive activity without toxicity.
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References
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References
M. Asif, Biological Potential and Chemical Properties of Pyridine and Piperidine Fused Pyridazine Compounds: Pyridopyridazine A Versatile Nucleus, Asian J. Chem. Pharm. Sci., 1, 29 (2016); https://doi.org/10.18311/ajcps/2016/7693
A.A. Altaf, A. Shahzad, Z. Gul, N. Rasool, A. Badshah, B. Lal and E. Khan, A Review on the Medicinal Importance of Pyridine Derivatives, J. Drug Design Med. Chem., 1, 1 (2015).
P.P. Parashar, Introductory Chapter: Pyridine, Intechopen, pp. 10-22 (2018).
D.S. Rekunge, I.A. Kale and G.U. Chaturbhuj, An Efficient Green Solvent Free Protocol for the Synthesis of 2,4,6 -Triarylpyridines Using Reusable Heterogenous Activated Fuller’s Earth Catalyst, J. Iranian Chem. Soc., 15, 2455 (2018); https://doi.org/10.1007/s13738-018-1434-8
A. Isvoran, A.A. Ciosac and V. Ostafe, ADME-Tox Profiling of Some Low Molecular Weight Water Soluble Chitosan Derivatives, ADMET DMPK, 5, 192 (2017); https://doi.org/10.5599/admet.5.3.423
W. Hong, What ADME Tests should be Conducted for Preclinical Studies? ADMET DMPK, 1, 19 (2013); https://doi.org/10.5599/admet.1.3.9