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Abstract

A convenient and efficient synthesis of 1,3-dimethyl-5-benzylidenebarbituric acid derivatives via gold nanoparticles is carried out. The gold nanoparticles were initiated from novel and low-cost goldsmith effluent source using green reducing agent D-glucose. By mediating autoclave at 121 ºC and 15 lb/cm2 pressure, these particles were further uniformly synthesized by using microwave radiation. The catalyst was analyzed using UV, IR and scanning electron microscopic techniques. Synthesized 1,3-dimethyl-5-benzylidene-barbituric acid was assayed to study its inhibitory action against TAU protein.

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Green synthesis Gold nanoparticles 1 3-Dimethyl-5-benzylidene Barbituric acid.

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Thakare, S., Borhade, A., & Patil, T. (2021). Green Synthesis of Barbituric Acid Derivative via Goldsmith Effluent Initiated Gold Nanoparticles and its Molecular Docking Study against Alzheimer Drug Target. Asian Journal of Organic & Medicinal Chemistry, 6(3), 175–180. https://doi.org/10.14233/ajomc.2021.AJOMC-P332
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