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Abstract

A new series of 1,2,3-triazole linked mercaptobenzoxazole/oxazolo[4,5-b]pyridine-2-thiol derivatives (6a-j) were synthesized starting from 2-aminophenol/2-aminopyridin-3-ol in three steps via cyclization, alkylation followed by reaction with various aromatic azides using click chemistry approach. All the synthesized compounds were evaluated for their antimicrobial activity viz. E. coli, P. aeruginosa, S. aureus and S. pyogenus and three pathogenic fungi viz. C. albicans, A. niger and A. clavatus and promising compounds were identified.

Keywords

Mercaptobenzoxazole Oxazolo[4 5-b]pyridine-2-thiol Sharpless condition Antibacterial activity Antifungal activity.

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Gour, P., Deshmukh, L., Dadmal, T., & Ramteke, A. (2021). Synthesis and Antimicrobial Activity of 1,2,3-Triazole Linked Benzo[d]oxazole-2-thiol/oxazolo[4,5-b]pyridine-2-thiol Derivatives. Asian Journal of Organic & Medicinal Chemistry, 6(1), 7–12. https://doi.org/10.14233/ajomc.2021.AJOMC-P293
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