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Abstract

Pyrazolo[3,4-d]pyrimidine derivatives were synthesized from 4-hydrazino-7-methoxy quinoline (2) with ethoxymethylenecyanoacetate afforded ethyl 5-amino-1-(7-methoxyquinolin-4-yl)-1H-pyrazole-4- carboxylate (3). The compound 3 was hydrolyzed to get 5-amino-1- (7-methoxyquinolin-4-yl)-1H-pyrazole-4-carboxylic acid (4) and then reacted with acetic anhydride to afford 1-(7-methoxyquinolin-4-yl)- 6-methylpyrazolo[3,4-d][1,3]oxazin-4(1H)-one (5), which was condensed with different aromatic amines to give a series of 5- substituted 1-(7-methoxyquinolin-4-yl)-6-methyl-5-aryl-1,5-dihydro- 4H-pyrazolo[3,4-d]pyrimidin-4-one (6). The newly synthesized compounds were characterized and evaluated for their antibacterial and antioxidant activity,and molecular docking studies.

Keywords

4-Hydrazino-7-methoxy quinolines Pyrazolopyrimidines Antimicrobial Antioxidant Molecular docking

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Dharshan, J., Vishnumurthy, K., Bodke, Y., Jayanna, N., & Mohammed Shafeeulla, R. (2016). Synthesis, Evaluation and Molecular Docking Studies of Some Novel Pyrazolo[3,4-d]pyrimidine Derivatives of 7-Methoxy Quinoline. Asian Journal of Organic & Medicinal Chemistry, 1(1), 10–16. https://doi.org/10.14233/ajomc.2016.AJOMC-P5
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