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Abstract

The Baylis-Hillman reaction was greatly accelerated in the presence of Fe3O4 magnetic nanoparticles as an efficient and reusable cocatalyst and 1,8-diazabicyclo[5.4.0]undec-7-ene in a solvent free medium. A preliminary kinetic study revealed that the relative rate of the reaction using Fe3O4 magnetic nanoparticles was considerably faster than that of reaction without Fe3O4 magnetic nanoparticles. In this protocol the use of nanocatalyst provided a green, useful and rapid method to generate the Baylis-Hillman adducts in short reaction times and excellent yields (82-94 %).

Keywords

Baylis-Hillman reaction Rate acceleration Fe3O4 magnetic nanoparticles Solvent free medium 1,8-Diazabicyclo[5.4.0]undec-7-ene

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Badrian, A. (2017). Dramatic Rate Acceleration of Baylis-Hillman Reaction with Fe3O4 Magnetic Nanoparticles and 1,8-diazabicyclo[5.4.0]undec-7-ene in Solvent Free Medium. Asian Journal of Organic & Medicinal Chemistry, 1(4), 132–137. https://doi.org/10.14233/ajomc.2016.AJOMC-P45
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