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Abstract

In the present study, a variety of novel tramadol esters (2-6) were synthesized via the reaction of (±)-cis-2-[(dimethylamino)methyl]- 1-(3-methoxy-phenyl)cyclohexanol (tramadol) (1) with acid chlorides and triethylamine. Treatment of compound 1 with epichlorohydrin afforded corresponding ether derivative 7. The reaction of compound 1 with isothiocyanates gave the novel carbamothioate derivatives 8- 12. Tramadol derivatives were found more sensitive for detection with (HPLC-DAD) than tramadol itself.

Keywords

Tramadol Esters Carbamothioates Isothiocyanate HPLC

Article Details

How to Cite
Khodiary, A., Ahmed, E., M. Mohamed, K., & A. Thabet, S. (2017). Synthesis of Esters and Carbamothioates Contaminating Tramadol Moiety and Their HPLC Applications. Asian Journal of Organic & Medicinal Chemistry, 2(1), 23–28. https://doi.org/10.14233/ajomc.2017.AJOMC-P62

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