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Abstract
The interaction of drugs (troxerutin, dibazol and reserpine) to bovine serum albumin (BSA) and serum was investigated by UV-visible spectroscopy under simulative physiological conditions. The results showed that there is a kind of new complex between drugs and bovine serum albumin and serum. Comparing the absorption spectra of interaction between three drugs and bovine serum albumin, it can be concluded that there is a large interaction in the system of reserpine with bovine serum albumin and there is a large blue in the system of dibazol and bovine serum albumin. It is significant to study the interaction between drugs and bovine serum albumin and serum for understanding of troxerutin’s toxicity and its distribution in the organism.
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References
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References
U. Kragh-Hansen, Pharm. Rev., 33, 17 (1981).
G.W. Zhang, A.Q. Wang and T. Jiang, Guangpuxue Yu Guangpu Fenxi, 28, 908 (2008).
S. Ashoka, J. Seetharamappa, P.B. Kandagal and S.M.T. Shaikh, J. Lumin., 121, 179 (2006); https://doi.org/10.1016/j.jlumin.2005.12.001.
A. Russo, R. Acquaviva, A. Campisi, V. Sorrenti, C. Di Giacomo, G. Virgata, M.L. Barcellona and A. Vanella, Cell Biol. Toxicol., 16, 91 (2000); https://doi.org/10.1023/A:1007685909018.
F. Wang, W. Huang, L. Su, Z. Dong and S. Zhang, J. Mol. Struct., 927, 1 (2009); https://doi.org/10.1016/j.molstruc.2009.01.022.
L. Strzemecka and Z. Urbañczyk-Lipkowska, J. Mol. Struct., 970, 1 (2010); https://doi.org/10.1016/j.molstruc.2009.05.016.
T.H. Wang, Z.M. Zhao, J. Hua and J. Zhang, Indian J. Biochem. Biophys., 48, 388 (2011).
T.H. Wang and Z.M. Zhao, Asian J. Chem., 24, 1242 (2012);
W.K. Surewicz, H.H. Mantsch and D. Chapman, Biochemistry, 32, 389 (1993); https://doi.org/10.1021/bi00053a001.