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Abstract

The present work describes the synthesis and biological evaluation of substituted 1,2,4-triazole derivatives. Synthesis is carried out by the condensation reaction of benzothiamide derivative with 2,2,2-trifluoroacetohydrazide to give 1,2,4-triazole, which was further modified by N-alkylation and Suzuki– Miyaura coupling reaction. Furthermore, the characterization of the product is carried out by elemental analysis and spectral analysis. Products were evaluated for their in vitro biological assay for antibacterial activity against various bacterial standard strains, i.e. Staphylococcus aureus MTCC-96, Streptococcus pyogenes-MTCC-443, two Gram-negative bacteria Escherichia coli MTCC-442, Pseudomonas aeruginosa-MTCC-441 and three fungal strains Candida albicans MTCC-227, Aspergillus niger MTCC- 282, Aspergillus clavatus MTCC-1323 at different concentrations and the results were compared with standard drugs.

Keywords

Triazole Methylation N-Butylation Solvent Spectroscopy Suzuki–Miyaura coupling

Article Details

How to Cite
Singala, P., Talpara, P., & Shah, V. (2018). Design, Synthesis and Biological Screening of Novel 1,2,4-Triazoles Employing Suzuki-Miyaura Coupling Reaction. Asian Journal of Organic & Medicinal Chemistry, 3(1), 14–17. https://doi.org/10.14233/ajomc.2018.AJOMC-P97
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