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Abstract

In the present work, we synthesized some acridone derivatives and formed inclusion complex with cyclodextrin to improve the solubility. Thermodynamic parameters of the complexes were evaluated. Antimicrobial test was performed to evaluate the potentiality of the synthesized compounds or complexes as drugs.

Keywords

Acridone Bioavailability Inclusion complex β-Cyclodextrin

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Sahu, S., & Kumar Padhy, R. (2018). Enhancement of Bioavailability of Pharmaceutically Active Acridone Derivatives by Inclusion Complex Formation with β-Cyclodextrin as Encapsulate. Asian Journal of Organic & Medicinal Chemistry, 3(2), 45–49. https://doi.org/10.14233/ajomc.2018.AJOMC-P123
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References

  1. S.F. Queener, H. Fujioka, Y. Nishiyama, H. Furukawa, M.S. Bartlett and J.W. Smith, in vitro Activities of Acridone Alkaloids against Pneumo-cystis carinii, Antimicrob. Agents Chemother., 35, 377 (1991); https://doi.org/10.1128/AAC.35.2.377.
  2. A. Putic, L. Stecher, H. Prinz and K. Müller, Structure-Activity Relation-ship Studies of Acridones as Potential Antipsoriatic Agents. 2. Synthesis and Antiproliferative Activity of 10-Substituted Hydroxy-10H-Acridin-9-Ones against Human Keratinocyte Growth, Eur. J. Med. Chem., 45, 5345 (2010); https://doi.org/10.1016/j.ejmech.2010.08.059.
  3. J.X. Kelly, J.M. Smilkstein, R.A. Cooper, K.D. Lane, R.A. Johnson, A. Janowsky, R.A. Dodean, D.J. Hinrichs, R. Winter and M. Riscoe, Design, Synthesis, and Evaluation of 10-N-Substituted Acridones as Novel Chemosensitizers in Plasmodium falciparum, Antimicrob. Agents Chemother., 51, 4133 (2007); https://doi.org/10.1128/AAC.00669-07.
  4. A. Stankiewicz-Drogon, L.G. Palchykovska, V.G. Kostina, I.V. Alexeeva, A.D. Shved and A.M. Boguszewska-Chachulska, New Acridone-4-Carboxylic Acid Derivatives as Potential Inhibitors of Hepatitis C Virus Infection, Bioorg. Med. Chem., 16, 8846 (2008); https://doi.org/10.1016/j.bmc.2008.08.074.
  5. J. Salimon, N. Salih, E. Yousif, A. Hameed and A. Kreem, Synthesis and Pharmacological Evaluation of 9(10H)-Acridone Bearing 1,3,4-Oxadiazole Derivatives as Antimicrobial Agents, Arab. J. Chem., 3, 205 (2010); https://doi.org/10.1016/j.arabjc.2010.06.001.
  6. S.D. Bhattamishra and R.K. Padhy, Estimation of Ibuprofen Solubil-ization in Cationic and Anionic Surfactant Media: Application of Micelle Binding Model, Indian J. Chem. Technol., 16, 426 (2009).
  7. C.O. Rangel-Yagui, A. Pessoa Jr. and L.C. Tavares, Micellar Solubil-ization of Drugs, J. Pharm. Pharm. Sci., 8, 147 (2005).
  8. T. Loftsson, P. Jarho, M. Masson and T. Jarvinen, Cyclodextrins in Drug Delivery, Expert Opin. Drug Deliv., 2, 335 (2005); https://doi.org/10.1517/17425247.2.1.335.
  9. S. Nie, X. Fan, Y. Peng, X. Yang, C. Wang and W. Pan, In Vitro and in vivo Studies on the Complexes of Vinpocetine with Hydroxypropyl-b-Cyclo-dextrin, Arch. Pharm. Res., 30, 991 (2007); https://doi.org/10.1007/BF02993968.
  10. T. Stalin, P.V. Rani, B. Shanti, A. Sekhar and N. Rajendran, Inclusion Complex of 1,2,3-Trihydroxybenzene with a- and b-Cyclodextrins, Indian J. Chem., 45A, 1113 (2006).
  11. M.B. Coyle, Manual of Antimicrobial Susceptibility Testing, American Society for Microbiology, USA, p. 39 (2005).
  12. F.G. Mann and B.C. Saunders, Practical Organic Chemistry, Longman Inc., New York, p. 303 (1978).
  13. V.T. Karathanos, I. Mourtzinos, K. Yannakopoulou and N.K. Andrikopoulos, Study of the Solubility, Antioxidant Activity and Structure of Inclusion Complex of Vanillin with b-Cyclodextrin, Food Chem., 101, 652 (2007); https://doi.org/10.1016/j.foodchem.2006.01.053.
  14. T. Higuchi and K.A. Connors, Adv. Anal. Chem. Instrum., 4, 117 (1965).
  15. S. Tommasini, D. Raneri, R. Ficarra, M.L. Calabro, R. Stancanelli and P. Ficarra, , J. Pharm. Biomed. Anal., 35, 379 (2004); https://doi.org/10.1016/S0731-7085(03)00647-2.
  16. H.A. Benesi and J.H. Hildebrand, A Spectrophotometric Investigation of the Interaction of Iodine with Aromatic Hydrocarbons, J. Am. Chem. Soc., 71, 2703 (1949); https://doi.org/10.1021/ja01176a030.
  17. J. Szejtli, W.F. Smolen and L.A. Ball, Controlled Drug Bioavailability, Wiley Interscience, New York, USA, p. 365 (1985).
  18. R.A. Rajewski and V.J. Stella, Pharmaceutical Applications of Cyclo-dextrins. 2. In Vivo Drug Delivery, J. Pharm. Sci., 85, 1142 (1996); https://doi.org/10.1021/js960075u.
  19. Y.L. Loukas, V. Vraka and G. Gregoriadis, Novel Non-Acidic Formulations of Haloperidol Complexed with b-Cyclodextrin Derivatives, J. Pharm. Biomed. Anal., 16, 263 (1997); https://doi.org/10.1016/S0731-7085(97)00029-0.
  20. A. Cooper and D.D. MacNicol, Chiral Host-Guest Complexes: Inter-action of a-Cyclodextrin with Optically Active Benzene Derivatives, J. Chem. Soc. Perkin Trans. II, 760 (1978); https://doi.org/10.1039/P29780000760.