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Abstract

New 2-methylsulphonyl amino-4-arythio methyl thiazoles (6a-f) have been synthesized by novel route starting from 1,3-dichlroacetone (1) and thiourea (2), by multistep synthesis which involves cyclocondensation, mesylation and thioetherification. Synthesized intermediates and final compounds were characterized by IR, 1H NMR, mass spectroscopic techniques and elemental analysis. Synthesized titled compounds were evaluated for in vitro anti-inflammatory activity by the human red blood cell membrane stabilization method. The compounds 6c, 6d, 6e and 6f displayed good anti-inflammatory activity as compared with standard diclofenac sodium.

Keywords

2-Amino-4-chloromethylthiazole hydrochloride Mesylation Arythiols Anti-inflammatory activity

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A. Waghmare, R., L. Lingampalle, D., B. Jagrut, V., & Asrondkar, A. (2018). Synthesis and in vitro Anti-inflammatory Activity of Some 2-(Methylsulphonyl Amino)- 4-(Arylthio)methyl Thiazoles. Asian Journal of Organic & Medicinal Chemistry, 3(2), 29–33. https://doi.org/10.14233/ajomc.2018.AJOMC-P92
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