Main Article Content

Abstract

The present study explores the active bioconstituents of n-butanolic extracts of Flacourtia jangomas fruits and evaluate its anticancer potentiality based on the evidences from the ethnomedicianl practice of the plant. In this work, in vivo model was used to evaluate the anticancer activity. Hematological profiles were found to be nearly normal level in extract treated mice compared with tumor bearing control mice.

Keywords

Flacourtia jangomas Dalton cell line Flavonoids

Article Details

How to Cite
Das, S., Dash, S., Laloo, D., Dasgupta, D., & Moni Kalita, J. (2018). Anticancer Activity of Active Constituents Isolated from n-Butanolic Extracts of Flacourtia jangomas (Salicaceae). Asian Journal of Organic & Medicinal Chemistry, 3(3), 89–94. https://doi.org/10.14233/ajomc.2018.AJOMC-P121

References

  1. H. Kuper, P. Boffetta and H.O. Adami, Tobacco Use and Cancer Causation: Association by Tumour Type, J. Intern. Med., 252, 206 (2002); https://doi.org/10.1046/j.1365-2796.2002.01022.x.
  2. N. Dashora, V. Sodde, B. Jaykumar, S.P. Kriti and L. Richard, Antitumor Activity of Dendrophthoe falcate against Ehrlich Ascites Carcinomain Swiss Albino Mice, Pharm. Crops, 2, 1 (2011); https://doi.org/10.2174/2210290601102010001.
  3. D.A. Nelson, T.T. Tan, A.B. Rabson, D. Anderson, K. Degenhardt and E. White, Hypoxia and Defective Apoptosis Drive Genomic Instability and Tumorigenesis, Genes Dev., 18, 2095 (2004); https://doi.org/10.1101/gad.1204904.
  4. M.S. Dhanamani, D.S. Lakshmi and S. Kannan, Ethnomedicinal Plants for Cancer Therapy-A Review, Hygeia J. Drugs Med., 3, 1 (2011).
  5. F. Parmer, N. Kushawaha, H. Highland and L.B. George, in vitro Anti-oxidant and Anticancer activity of M. Pudica extract, Int. J. Pharm. Res., 7, 50 (2014).
  6. B. Ramesh and M. Pratheeba, Asian J. Pharm. Clin. Res., 7, 213 (2014).
  7. A. Akthar, S. Zaman, A.M. Umar, M.Y. Ali and M.A. Jalil Miah, Isol-ation of Polyphenolic Compounds from the Green Coconut (Cocos nucifera) Shell and Characterization of their Benzoyl Ester Derivatives, J. Sci. Res., 2, 186 (2010); https://doi.org/10.3329/jsr.v2i1.2659.
  8. W. Tao, L. Jianbo, Y. Yang, R. Abdulla, J. Chen and H.A. Aisa, Preparative Isolation of Three Flavonoids from Flos gossypii by High-speed Counter-current Chromatography, Sep. Purif. Technol., 66, 295 (2009); https://doi.org/10.1016/j.seppur.2008.12.024.
  9. A.A. Adegoke and B.C. Adebayo-tayo, Antibacterial Activity and Phyto-chemical Analysis of Leaf Extracts of Lasienthera asfricanum, Afr. J. Biotechnol., 8, 77 (2009).
  10. T.P. Green, M. Fennell, R. Whittaker, J. Curwen, V. Jacobs, J. Allen, A. Logie, J. Hargreaves, D.M. Hickinson, R.W. Wilkinson, P. Elvin, B. Boyer, N. Carragher, P.A. Plé, A. Bermingham, G.A. Holdgate, W.H.J. Ward, L.F. Hennequin, B.R. Davies and G.F. Costello, Preclinical Anticancer Activity of Potent, Oral Src Inhibitor AZD0530, Mol. Oncol., 3, 248 (2009); https://doi.org/10.1016/j.molonc.2009.01.002.
  11. X. Zhou, J. Peng, G. Fan and Y. Wu, Isolation and Purification of Flavo-noid Glycosides from Trollius Ledebouri using High-speed Counter-Current Chromatography by Stepwise Increasing the Flow-Rate of the Mobile Phase, J. Chromatogr. A, 1092, 216 (2005); https://doi.org/10.1016/j.chroma.2005.07.064.
  12. D. Debaprotim and D. Suvakanta, Asian J. Pharm. Clin. Res., 10, 266 (2017); https://doi.org/10.22159/ajpcr.2017.v10i7.18514.
  13. M. Gupta, U.K. Mazumder, P.K. Haldar, C.C. Kandar, L. Manikandan and G.P. Senthil, Anticancer Activity of Indigofera aspalathoides and Wedelia calendulaceae in Swiss Albino Mice, Iran. J. Pharm. Res., 6, 141 (2007).
  14. T. Fotsis, M.S. Pepper, E. Aktas, S. Breit, S. Rasku, H. Adlercreutz, K. Wahala, R. Montesano and L. Schweigerer, Flavonoids, Dietary-Derived Inhibittors of Cell Proliferation and in vitro Angiogenesis, Cancer Res., 57, 2916 (1997).
  15. N.M. Hamid, M.A. Fawzy and M. A. El-Moselhy, Evaluation of Hepatoprotective and Anticancer Properties of Aqueous Olive Leaf Extract in Chemically Induced Hepatocellular Carcinoma in Rats, Am. J. Med. Med. Sci., 1, 15 (2011); https://doi.org/10.5923/j.ajmms.20110101.03.
  16. S. Nisa, B. Yamin, W. Abdul, Z. Muhammad, S. Sadia, S. Sabbir and M. Fayyaz, Evaluation of Anticancer activity of Debregeasia salicifolia Extract against Estrogen Receptor Positive Cell Line, Afr. J. Biotechnol., 10, 990 (2011).