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Abstract

Unusual and new bis-β-lactams substituted at the 2,7-position of the phenanthrene and 9,10- dihydrophenanthrne ring are prepared via Staudinger ketene-imine [2+2] cycloaddition reaction. This methodology is recognized as one of the most important and direct accesses route to β-lactams. The diastereoselectivity of cycloaddition processes is controlled by the structures of ketene and imine. The bulky group in the ketene and imine have a great influence on the stereochemical outcome of the β-lactam ring.

Keywords

Cycloaddition Ketene Unusual phenanthrene Imine Bis β-lactams

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Naresh Yadav, R., Marquez, J., Kumar Srivastava, A., Kumar Singh, A., & Krishna Banik, B. (2018). Novel Synthesis of Bis-β-Lactams with Unusual 2,7-Phenanthrene and 9,10-Dihydrophenanthrene Derivatives. Asian Journal of Organic & Medicinal Chemistry, 3(3), 85–88. https://doi.org/10.14233/ajomc.2018.AJOMC-P110
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