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Abstract

Starting from N-boc-protected 3-formylindole, practical synthesis of carbazole alkaloids clausine E, mukonine, koenoline, murrayafoline A and murrayanine has been accomplished in overall seven steps. The application of dimethyl maleate to construct the suitably substituted aromatic ring and selective transformation of mukonine to murraya-foline A are the important features.

Keywords

3-Formylindole Wittig reaction Intramolecular cyclization Selective reductions Carbazole alkaloids

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How to Cite
B. Markad, S., & P. Argade, N. (2018). Collective Synthesis of Basic Carbazole Alkaloids. Asian Journal of Organic & Medicinal Chemistry, 3(3), 65–68. https://doi.org/10.14233/ajomc.2018.AJOMC-P99
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