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Abstract

A series of pyrimidine-2-thione derivatives were newly synthesized starting from 2,3-dimethyl-6,7,8,9- tetrahydro-5H-benzocyclohepten-5-one (1). The antitumor activity of the synthesized compounds was evaluated against 5 human tumor cell lines. Some of the tested compounds are shown better anticancer activity against HeLa (human tumor cell). Additionally some more compounds are showing good to moderate activity against MCF7 (human breast adenocarcinoma cell lines).

Keywords

Benzosuberones Arylidene derivatives Pyrimidine-2- thiones Anti-cancer activity

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Rupavani, B., & Venkateswarlu, P. (2018). Synthesis and Anticancer Activities of Novel Pyrimidine-2-Thione Derivatives from Benzosuberones. Asian Journal of Organic & Medicinal Chemistry, 3(4), 155–158. https://doi.org/10.14233/ajomc.2018.AJOMC-P142
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