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Abstract

A simple, green and efficient catalytic condensation process have been developed to synthesize the series of 2-amino-6-substituted-4,6-diphenyl-3′,4,4′,5-tetrahydro[4,5′-bipyrimidine]-2′(1H)-one (3a-j) hybrids. The catalytic route was investigated efficiently in presence of NaY zeolite in organicaqueous (dichloromethane-water) solvent system. In this method, biphasic solvent systems were explored for suitable applicability where catalyst exhibits remarkable reactivity. Synthesized compounds were screened for their in vitro antibacterial activity against Staphylococcus aureus, E. coli and Pseudomonas aurigenosa and also antifungal activity against the opportunistic pathogens Candida albicans and Aspergillus niger. Among them compounds 3d, 3e, 3f and 3i exhibited very good inhibition activity for antibacterial and antifungal. All the synthesized compounds were characterized by IR, 1H NMR, 13C NMR, mass and CHN analyses.

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Bipyrimidines Zeolite Dichloromethane-water biphasic system Antimicrobial activity

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S. Aswale, M., & P. Dhankar, R. (2018). Synthesis and Antimicrobial Evaluation of Bipyrimidines in Efficient Biphasic System using Zeolite as Green Catalyst. Asian Journal of Organic & Medicinal Chemistry, 3(4), 143–149. https://doi.org/10.14233/ajomc.2018.AJOMC-P140
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