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Abstract

2-Amino-5-phenyl-1,3,4-thiadiazole on reaction with ethyl-2-cyano-3,3-bis(methylthio)acrylate in the presence of N,N′-dimethyl formamide and catalytic amount of anhydrous potassium carbonate afforded 7-(methylthio)-5-oxo-2-phenyl-5H-[1,3,4]thiadiazolo[3,2-b]pyrimidine-6-carbonitrile under similar experimental condition, compounds 7-(methylthio)-5-oxo-2-phenyl-5H-[1,3,4]thiadiazolo[3,2-b]pyrimidine-6-carbonitrile on treatment independently with aryl amines/ heteryl amines/phenols containing active methylene group yielded corresponding 7-substituted derivatives. All these newly synthesized compounds were screened for antimicrobial activity.

Keywords

Pyrimido-thiadiazoles Antimicrobial activity

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How to Cite
A. Angulwar, J., S. Khansole, G., & N. Bhosale, V. (2019). Novel Synthesis and Antimicrobial Activity of 7-Substituted Derivatives of 7-(methylthio)-5-oxo-2-phenyl-5H-[1,3,4]thiadiazolo[3,2-b]pyrimidine-6-carbonitrile. Asian Journal of Organic & Medicinal Chemistry, 4(1), 40–45. https://doi.org/10.14233/ajomc.2019.AJOMC-P171
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