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Abstract

A series of new 6-(2-oxo-3-[(4-arylpiperazino)carbonyl]-2H-6-chromenyl-methyl)-3-[(4- arylpiperazino)carbonyl]-2H-2-chromenone 9(a-j) have been synthesized and tested for their antibacterial activity against human pathogenic strains. The antibacterial evaluation data revealed that the compounds containing 4-methoxyphenyl, 4-fluorophenyl, 4-nitrophenyl and 4-hydroxyphenyl moieties at 4-position of the piperazine ring exhibited potent inhibitory activity towards all the tested bacterial strains. Further, the compounds containing phenyl and 4-methylphenyl moieties showed good activity towards P. aeruginosa and C. violaceum. The 4-nitrophenyl moiety also showed potent activity towards B. subtilis and B. sphaericus.

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Methylene-bis-coumarin Piperazine Antibacterial activity

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Nagaraj, A., Srinivas, S., Ramesh Naik, P., & Neelofer, R. (2019). Synthesis and Antibacterial Study of Novel Piperazine Linked Methylene-bis-Coumarins. Asian Journal of Organic & Medicinal Chemistry, 4(2), 101–108. https://doi.org/10.14233/ajomc.2019.AJOMC-P177
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