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Abstract

Coumarin derivatives are an important class of heterocyclic compounds, specifically 4-amino substituted coumarins with antioxidant, anticancer activities. The above observations prompted us to synthesize new coumarins with various substitutions. The starting material 4-chloro-2H-chromen-2-one was synthesized by refluxing a mixture of 4-hydroxy-2H-chromen-2-one in phosphoryl chloride. The 4-substituted amine derivatives of coumarin were synthesized by refluxing 4-chloro-2H-chromen-2-one with 4-substituted amines and anhydrous K2CO3 and methanol. All the eleven 4-substituted amine derivatives of coumarin were synthesized by replacing chloro group with different amines. These coumarin derivatives were evaluated for in vitro antioxidant activity using quercetin as standard.

Keywords

Coumarins Antioxidant activity Molecular docking

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Ukirde, R., Patil, R., & Sawant, S. (2019). Design, Synthesis and Evaluation of Antioxidant Activity of Some Coumarin Derivatives. Asian Journal of Organic & Medicinal Chemistry, 4(3), 138–143. https://doi.org/10.14233/ajomc.2019.AJOMC-P172
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