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Abstract

The present study demonstrated the antioxidant activity of 2-bromo- 3-hydroxy-2-nitropropylcinnamate versus alcohol induced oxidative damage in albino wistar rats. In this study, 30 % alcohol exposed rats were found to be more prone to peroxidative risk as they are calculated by species of thiobarbituric acid. It was observed that after the rats induction with 30% alcohol, concentration of lipid peroxidation has been obtained expressively (p ≤ 0.001) high in a liver and serum, beside with concomitant substantial (p ≤ 0.001) reduced in enzymatic and non-enzymatic antioxidants levels like catalase (CAT), superoxide dismutase (SOD), glutathione reductase (GR), glutathione peroxidase (GPx), vitamin E (tocopherol), reduced glutathione (GSH), glutathione- s-transferase (GST), vitamin C (ascorbic acid), β-carotene as well as ceruloplasmin in serum along with liver, only 30% alcohol was treated. If rats obtained 2-bromo-3-hydroxy-2-nitropropylcinnamate at the dose level of 20 mg/kg bw/day, PO, for 30 days, the peroxidative damage has been marginal in serum along with liver, alongside efficiently encouraging the potential of antioxidant in the rats treated by alcohol. This study revealed that in liver the raised peroxidative risk is probably allied with alcohol induction pathology that can be decreased by increasing the antioxidant potential by free radical scavenging activity, therefore promising as artificial antioxidants for 2-bromo-3- hydroxy-2-nitropropylcinnamate.

Keywords

2-Bromo-3-hydroxy-2-nitropropylcinnamate Antioxidant activity Lipid peroxidation

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Kumar Malik, R., Kumar Singh, D., Kumar, S., & Anuradha, . (2020). Antioxidant Activity of 2-Bromo-3-hydroxy-2- nitropropylcinnamate against Alcohol Induced Oxidative Damage in Rats. Asian Journal of Organic & Medicinal Chemistry, 5(2), 156–160. https://doi.org/10.14233/ajomc.2020.AJOMC-P266
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