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Abstract

Efferent, new and simple synthesis for antidepressant drug moclobemide has been developed via two liner steps. Initially, morpholine was treated with 60% aqueous solution of 2-bromoethylamine hydrochloride under solvent and catalyst free condition leads to a key intermediate N-(2-aminoethyl)morpholine, which subsequently treated with p-chlorobenzoic acid in presence of commercially available solid catalysts, afforded moclobemide with good yield. Mild reaction conditions, short reaction time, easy workup, cost-effective, environment friendliness and high yields are attractive advantages of the present method, so our synthetic strategy was applicable to large scale manufacturing of moclobemide every conveniently.

Keywords

N-(2-Aminoethyl)morpholine Moclobemide N-Alkylation Direct amidation

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M. Potdar, S., & T. Waghmode, K. (2020). An Efficient Straightforward Synthesis of Antidepressant Drug Moclobemide. Asian Journal of Organic & Medicinal Chemistry, 5(2), 174–178. https://doi.org/10.14233/ajomc.2020.AJOMC-P268
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