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Abstract

With the aim to develop an efficient strategy to synthesize pyrimidine derivatives bearing diversely substituted amines involves four step linear protocols started with Biginelli multi-component reaction leading to dihydropyrimidines which passing throug multistep sequantial process containing oxidation, chlorination and catalytically free transformation of pyrimidin-2(1H)-one to 2-(N-arylamino)pyrimidines, were evaluated for cytotoxicity study against human cancer lines HCT-116, Hep-G2 and QG-56. Compound 4j exhibit significant anticancer activity showed against: human hepato carcinoma (Hep-G2) and human colon carcinoma (HCT-116) serve as a excellent lead molecule for the generation of various promising targets.

Keywords

Biginelli Multi-component reaction Dihydropyrimidine Pyrimidin-2(1H)-one 2-(N-Arylamino) pyrimidines

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P. Chandrani, J., & J. Ganatra, K. (2020). An Efficient And Catalytically Free Chemical Transformation of Pyrimidin-2(1H)-one to 2-(N-Arylamino)pyrimidines and their in vitro Cytotoxicity Evaluation. Asian Journal of Organic & Medicinal Chemistry, 5(2), 133–137. https://doi.org/10.14233/ajomc.2020.AJOMC-P260
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