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Abstract

This study has investigated the possible mode of action of several phytochemicals known to possess anti-inflammatory and anti-cancer properties. It was found by molecular docking studies that ferulic acid, gallic acid, pcoumaric acid, vanillin, myrecene, 4-vinyl phenol and catechol interacted with the binding sight of TNF-α which is the chief regulator of inflammation. This study suggest a possible role of these phytochemicals as anticancer and anti-inflammatory agents.

Keywords

Anticancer Anti-inflammatory Molecular docking Phytochemicals Tumor necrosis factor-alpha (TNF-α)

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Dasgupta, D., Desai, M., Waichal, S., & P. Gupta, P. (2020). Molecular Docking Based Study and Analysis of Phytochemicals with TNF-α in Search of Anti-Inflammatory and Anticancer Agents. Asian Journal of Organic & Medicinal Chemistry, 5(2), 109–112. https://doi.org/10.14233/ajomc.2020.AJOMC-P252
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