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Abstract

In this article, acid hydrazide 2, a functional group, was synthesized by the reaction of (4-chloro-12-methyl-16,17-dihydro-15-thia-6,11-diaza-cyclopenta[a]phenanthren-7-ylsulfanyl)acetic acid ethyl ester (1) with hydrazine yield (4-chloro-12-methyl-16,17-dihydro-15-thia-6,11-diazacyclopenta[a]phenanthren-7-ylsulfanyl)acetic acid hydrazide (2) is discussed. The reactive acid hydrazide compound 2 was utilized for the synthesis of amides 3, Schiff’s bases 4 and thiazolidine 5 derivatives. The structures of target compounds were confirmed by elemental analysis and spectral data. The antimicrobial activity of new compounds were studied against Streptococcus sp., Bacillus megaterium, Staphylococcus aureus, Escherichia coli, Bacillus cereus, Bacillus subtilis, Proteus valgaris and Pseudomonas aeroginosa by the agar well diffusion method. Compounds 4b, 5a, 5b and 5c showed good antimicrobial activity.

Keywords

Oxothiazolidines Heterocyclic amines Antimicrobial activity

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P. Pagar, B. (2020). Synthesis and Antimicrobial Activity of Novel Oxothiazolidine Derivatives. Asian Journal of Organic & Medicinal Chemistry, 5(2), 91–96. https://doi.org/10.14233/ajomc.2020.AJOMC-P248
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