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Abstract

A series of thiophene conjugated isoxazoles were efficiently synthesized using a recyclable heterogeneous catalyst Amberlyst-15 in good yields. The synthesized new compounds 5(a-j) were characterized by spectral and elemental analysis and screened in vitro for their antimicrobial potencies. Amongst the synthesized series; compounds 5c and 5j having chloro substitution on both thiophene and aromatic ring exhibited excellent inhibition against the tested species.

Keywords

Amberlyst-15 Antibacterial Antifungal Chalcone Cyclocondensation

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Vagish, C., Renuka, N., Ajay Kumar, K., & Jayadevappa, H. (2020). Synthesis of Thienyl-Isoxazolines and in vitro Screening for their Antimicrobial Activity. Asian Journal of Organic & Medicinal Chemistry, 5(3), 208–212. https://doi.org/10.14233/ajomc.2020.AJOMC-P277
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