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Abstract

A series of tetracyclic thiazepine based pyrazoles (6a-j) have been synthesized and evaluated for antibacterial and antifungal activities. The newly synthesized compounds have been characterized by IR, 1H & 13C NMR, mass and elemental analyses. Compounds 6b (2-OCH3) and 6c (4-OCH3) have shown promising antibacterial, and 6g (3-NO2), 6f (2-NO2) and 6d (3,4-diOCH3) exhibited excellent an antifungal activity against standard drugs.

Keywords

Thiazepine Pyrazole Cyclization Antimicrobial activity

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B. Hirani, J., Pandya, M., & B. Koradiya, S. (2020). Synthesis, Spectral Analysis and Antibacterial Screening of Tetracyclic Thiazepine Based Pyrazole Derivatives. Asian Journal of Organic & Medicinal Chemistry, 5(4), 283–288. https://doi.org/10.14233/ajomc.2020.AJOMC-P281
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