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Vol. 28 No. 8 (2016): Vol 28 Issue 8

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Synthesis, Characterization and Biological Evaluation of Novel 1-N-Substituted Thiocarbomoyl-3-ferrocenyl-2-pyrazoline Derivatives

https://doi.org/10.14233/ajchem.2016.19851
Humaira Parveen
Department of Chemistry, Faculty of Science, University of Tabuk, Tabuk, Kingdom of Saudi Arabia
Raedah Aiyed Suliman Alatawi
Department of Chemistry, Faculty of Science, University of Tabuk, Tabuk, Kingdom of Saudi Arabia
Salman Ahmad Khan
Department of Chemistry, Faculty of Science, King Abdul Aziz University, Jeddah, Kingdom of Saudi Arabia
Mohammed Issa Al-Ahmdi
Department of Chemistry, Faculty of Science, University of Tabuk, Tabuk, Kingdom of Saudi Arabia
Sayeed Mukhtar
Department of Chemistry, Faculty of Science, University of Tabuk, Tabuk, Kingdom of Saudi Arabia
Amir Azam
Department of Chemistry, Faculty of Natural Sciences, Jamia Millia Islamia, New Delhi-110 025, India
Nadia H. Elsayed
Department of Chemistry, Faculty of Science, University of Tabuk, Tabuk, Kingdom of Saudi Arabia; Department of Polymers and Pigments, National Research Center, Dokki, Cairo 12311, Egypt

Corresponding Author(s) : Humaira Parveen

humaira_chem@yahoo.co.in

Asian Journal of Chemistry, Vol. 28 No. 8 (2016): Vol 28 Issue 8

Abstract

Some novel 1-N-substituted thiocarbomoyl-3-ferrocenyl-2-pyrazoline derivatives were synthesized and evaluated for in vitro antiamoebic activity against HM1:IMSS strain of Entamoeba histolytica. The results showed that most of the compounds exhibited promising activity (IC50 values in the range of 0.050-1.683 μM) than the reference drug metronidazole (IC50 = 1.78 μM). Active compounds were further screened for cytotoxicity against human embryonic kidney-293 (HEK-293) normal cell lines to ensure their toxic effect and the results revealed that active compounds were least toxic in the concentration range of 2.5-50 μM for 48 h and 2.5-25 μM for 72 h. At 100 μM for 48 h and at 50 μM for 72 h only four compounds 2c, 2h, 2k and 2l showed maximum viability and least cytotoxicity, respectively, concluding that all the screened compounds were least cytotoxic against human embryonic kidney-293 (HEK-293) normal cell lines in the concentration range of 2.5-50 and 2.5-25 μM.

Keywords

Novel ferrocenyl pyrazolines Entamoeba histolytica Cytotoxicity
Parveen, H., Suliman Alatawi, R. A., Khan, S. A., Al-Ahmdi, M. I., Mukhtar, S., Azam, A., & Elsayed, N. H. (2016). Synthesis, Characterization and Biological Evaluation of Novel 1-N-Substituted Thiocarbomoyl-3-ferrocenyl-2-pyrazoline Derivatives. Asian Journal of Chemistry, 28(8), 1835–1840. https://doi.org/10.14233/ajchem.2016.19851
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