Issue

Vol. 35 No. 9 (2023): Vol 35 Issue 9, 2023

Copyright (c) 2023 deepankar rath, BISWAKANTH KAR, GURUDUTTA PATTNAIK, pallishree bhukta

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

Flavonoids and their Role in the Remedy of Diabetes Mellitus: A Review

https://doi.org/10.14233/ajchem.2023.28082
Deepankar Rath
Department of Pharmacology, School of Pharmacy and Life Sciences, Centurion University of Technology and Management, Ramchandrapur, P.O. Jatni, Bhubaneswar-752050, India
https://orcid.org/0000-0001-9879-2605
Biswakanth Kar
Department of Pharmacology, School of Pharmaceutical Sciences, Siksha O Anusandhan University, Bhubaneswar-751030, Odisha, India, Email id-biswa_kanth2005@yahoo.co.in
https://orcid.org/0000-0002-4530-1005
Gurudutta Pattnaik
Department of Pharmaceutics, School of Pharmacy and Life Sciences, Centurion University of Technology and Management, Odisha, India-752050
https://orcid.org/0000-0002-3532-721X
Pallishree Bhukta
Department of Pharmacology, School of Pharmacy and Life Sciences, Centurion University of Technology and Management, Odisha, India-752050
https://orcid.org/0000-0002-5826-9569

Corresponding Author(s) : Biswakanth Kar

biswa_kanth2005@yahoo.co.in

Asian Journal of Chemistry, Vol. 35 No. 9 (2023): Vol 35 Issue 9, 2023

Abstract

The impact of diabetes mellitus on the health care system is significant due to its global prevalence affecting millions of individuals. This condition is commonly related with factors such as obesity, urbanization, and genetic alterations. Those with diabetes mellitus have elevated blood glucose levels because an inability to produce, secrete or bind to insulin causes a lowering of insulin levels. Flavonoids are phenolic compounds found in fruits, vegetables and fungi. Carbon atoms are comprised of 15 chains of three carbon atoms in a skeleton. The anthocyanidin family includes flavonoids, flavones, flavanones, isoflavones, flavanols and flavonoids. In addition to their antidiabetic properties, flavonoids also have antioxidant properties. Molecular mechanisms underlying the antidiabetic properties of dietary flavonoids are summarized in this review. Other natural compounds with antidiabetic properties include cosmosiin, didymin, diosmin, naringin, isosiennsetin, nobiletin, poncirin, quercetin, rhoifolin, sinensetin, naringenin, sudachitin, rutin, hesperidin and tangeretin, which also improve lipid and phospholipid metabolism. The progression of diabetes is influenced by diabetes biomarkers. Citrus flavonoids are therefore promising candidates for antidiabetic action, even though further research is necessary to prove their effectiveness.

Keywords

Diabetes mellitus Flavonoids hyperglycaemia Antidiabetic Glycaemic control
Rath, D., Kar, B., Pattnaik, G., & Bhukta, P. (2023). Flavonoids and their Role in the Remedy of Diabetes Mellitus: A Review. Asian Journal of Chemistry, 35(9), 2021–2030. https://doi.org/10.14233/ajchem.2023.28082
Download Citation
Endnote/Zotero/Mendeley (RIS)
BibTeX
References
  1. S. Akkati, K.G. Sam and G. Tungha, J. Clin. Pharmacol., 51, 796 (2011); https://doi.org/10.1177/0091270010376972
  2. T. Hussain, B. Tan, Y. Yin, F. Blachier, M.C. Tossou and N. Rahu, Oxid. Med. Cell. Longev., 2016, 7432797 (2016); https://doi.org/10.1155/2016/7432797
  3. M.J. Amiot, C. Riva and A. Vinet, Obes. Rev., 17, 573 (2016); https://doi.org/10.1111/obr.12409
  4. M. Galleano, V. Calabro, P.D. Prince, M.C. Litterio, B. Piotrkowski, M.A. Vazquez-Prieto, R.M. Miatello, P.I. Oteiza and C.G. Fraga, Ann. N. Y. Acad. Sci., 1259, 87 (2012); https://doi.org/10.1111/j.1749-6632.2012.06511.x
  5. M. Guasch-Ferré, J. Merino, Q. Sun, M. Fitó and J. Salas-Salvadó, Oxid. Med. Cell. Longev., 2017, 6723931 (2017); https://doi.org/10.1155/2017/6723931
  6. M.F. Mahomoodally, A. Gurib-Fakim and A.H. Subratty, Pharm. Biol., 43, 237 (2005); https://doi.org/10.1080/13880200590928825
  7. A.K. Pandey, Natl. Acad. Sci. Lett., 30, 383 (2007).
  8. G. Danaei, M.M. Finucane, Y. Lu, G.M. Singh, M.J. Cowan, C.J. Paciorek, J.K. Lin, F. Farzadfar, Y.-H. Khang, G.A. Stevens, M. Rao, M.K. Ali, L.M. Riley, C.A. Robinson, M. Ezzati, Lancet, 378, 31 (2011); https://doi.org/10.1016/S0140-6736(11)60679-X
  9. P. Zhang, T. Li, X. Wu, E.C. Nice, C. Huang and Y. Zhang, Front. Med., 14, 583 (2020); https://doi.org/10.1007/s11684-019-0729-1
  10. H. Yaribeygi, T. Sathyapalan, S.L. Atkin and A. Sahebkar, Oxid. Med. Cell. Longev., 2020, 8609213 (2020); https://doi.org/10.1155/2020/8609213
  11. C. Li and H. Schluesener, Crit. Rev. Food Sci. Nutr., 57, 613 (2017); https://doi.org/10.1080/10408398.2014.906382
  12. C.L. Millar, Q. Duclos and C.N.E. Blesso, Adv. Nutr., 8, 226 (2017); https://doi.org/10.3945/an.116.014050
  13. A. Rees, G.F. Dodd and J.P.E. Spencer, Nutrients, 10, 1852 (2018); https://doi.org/10.3390/nu10121852
  14. N.H. Zaidun, Z.C. Thent and A.A. Latiff, Life Sci., 208, 111 (2018); https://doi.org/10.1016/j.lfs.2018.07.017
  15. M.A. Cornier, D. Dabelea, T.L. Hernandez, R.C. Lindstrom, A.J. Steig, N.R. Stob, R.E. van Pelt, H. Wang and R.H. Eckel, Endocr. Rev., 29, 777 (2008); https://doi.org/10.1210/er.2008-0024
  16. A.J. Hanley, A.J. Karter, K. Williams, A. Festa, R.B. D’Agostino Jr., L.E. Wagenknecht and S.M. Haffner, Circulation, 112, 3713 (2005); https://doi.org/10.1161/CIRCULATIONAHA.105.559633
  17. A.S. Gami, B.J. Witt, D.E. Howard, P.J. Erwin, L.A. Gami, V.K. Somers and V.M. Montori, J. Am. Coll. Cardiol., 49, 403 (2007); https://doi.org/10.1016/j.jacc.2006.09.032
  18. E.J. Middleton Jr., Adv. Exp. Med. Biol., 439, 175 (1998); https://doi.org/10.1007/978-1-4615-5335-9_13
  19. I.C. Arts and P.C. Hollman, Am. J. Clin. Nutr., 81, 317S (2005); https://doi.org/10.1093/ajcn/81.1.317S
  20. P.C.H. Hollman, M.N.C.P. Bijsman, Y. van Gameren, E.P.J. Cnossen, J.H.M. de Vries and M.B. Katan, Free Radic. Res., 31, 569 (1999); https://doi.org/10.1080/10715769900301141
  21. C. Zagrean-Tuza, A.C. Mot, T. Chmiel, A. Bende and I. Turcu, Food Funct., 11, 5293 (2020); https://doi.org/10.1039/D0FO00319K
  22. D. Del Rio, L. Calani, F. Scazzina, L. Jechiu, C. Cordero and F. Brighenti, Nutrition, 26, 528 (2010); https://doi.org/10.1016/j.nut.2009.06.013
  23. A. Scalbert, C. Morand, C. Manach and C. Remesy, Biomed. Pharmacother., 56, 276 (2002); https://doi.org/10.1016/S0753-3322(02)00205-6
  24. J.P. Spencer, H. Schroeter, A.R. Rechner and C. Rice-Evans, Antioxid. Redox Signal., 3, 1023 (2001); https://doi.org/10.1089/152308601317203558
  25. L. Bravo, Nutr. Rev., 56, 317 (1998); https://doi.org/10.1111/j.1753-4887.1998.tb01670.x
  26. J.P.E. Spencer, F. Chaudry, A.S. Pannala, S.K. Srai, E. Debnam and C. Rice-Evans, Biochem. Biophys. Res. Commun., 272, 236 (2000); https://doi.org/10.1006/bbrc.2000.2749
  27. I.F.F. Benzie, Y.T. Szeto, J.J. Strain and B. Tomlinson, Nutr. Cancer, 34, 83 (1999); https://doi.org/10.1207/S15327914NC340112
  28. K. Hanhineva, R. Torronen, I. Bondia-Pons, J. Pekkinen, M. Kolehmainen, H. Mykkanen and K. Poutanen, Int. J. Mol. Sci., 11, 1365 (2010); https://doi.org/10.3390/ijms11041365
  29. K. Skryhan, L. Gurrieri, F. Sparla, P. Trost and A. Blennow, Front. Plant Sci., 9, 1344 (2018); https://doi.org/10.3389/fpls.2018.01344
  30. M. Mueckler, C. Caruso, S.A. Baldwin, M. Panico, I. Blench, H.R. Morris, W.J. Allard, G.E. Lienhard and H.F. Lodish, Science, 229, 941 (1985); https://doi.org/10.1126/science.3839598
  31. M. Mueckler and B. Thorens, Mol. Aspects Med., 34, 121 (2013); https://doi.org/10.1016/j.mam.2012.07.001
  32. P.V. Babu, D. Liu and E.R. Gilbert, J. Nutr. Biochem., 24, 1777 (2013); https://doi.org/10.1016/j.jnutbio.2013.06.003
  33. B.M. Burgering and P.J. Coffer, Nature, 376, 599 (1995); https://doi.org/10.1038/376599a0
  34. J.R. Zierath, L. He, A. Gumà, E.O. Wahlström, A. Klip and H. Wallberg-Henriksson, Diabetologia, 39, 1180 (1996); https://doi.org/10.1007/BF02658504
  35. A. Dresner, D. Laurent, M. Marcucci, M.E. Griffin, S. Dufour, G.W. Cline, L.A. Slezak, D.K. Andersen, R.S. Hundal, D.L. Rothman, K.F. Petersen and G.I. Shulman, J. Clin. Invest., 103, 253 (1999); https://doi.org/10.1172/JCI5001
  36. V. Aguirre, T. Uchida, L. Yenush, R. Davis and M.F. White, J. Biol. Chem., 275, 9047 (2000); https://doi.org/10.1074/jbc.275.12.9047
  37. K. Ozawa, M. Miyazaki, M. Matsuhisa, K. Takano, Y. Nakatani, M. Hatazaki, T. Tamatani, K. Yamagata, J. Miyagawa, Y. Kitao, O. Hori, Y. Yamasaki and S. Ogawa, Diabetes, 54, 657 (2005); https://doi.org/10.2337/diabetes.54.3.657
  38. Y. Lin, A.H. Berg, P. Iyengar, T.K. Lam, A. Giacca, T.P. Combs, M.W. Rajala, X. Du, B. Rollman, W. Li, M. Hawkins, N. Barzilai, C.J. Rhodes, I.G. Fantus, M. Brownlee and P.E. Scherer, J. Biol. Chem., 280, 4617 (2005); https://doi.org/10.1074/jbc.M411863200
  39. S. Furukawa, T. Fujita, M. Shimabukuro, Y. Yamada, Y. Nakajima, O. Nakayama, M. Iwaki, M. Makishima, M. Matsuda and I. Shimomura, J. Clin. Invest., 114, 1752 (2004); https://doi.org/10.1172/JCI21625
  40. P.J. Guillausseau, T. Meas, M. Virally, M. Laloi-Michelin, V. Medeau and J.P. Kevorkian, Diabetes Metab., 34, S43 (2008); https://doi.org/10.1016/S1262-3636(08)73394-9
  41. L.J. Yan, J. Diabetes Res., 2014, 137919 (2014); https://doi.org/10.1155/2014/137919
  42. M. Cnop, N. Welsh, J.C. Jonas, A. Jorns, S. Lenzen and D.L. Eizirik, Diabetes, 54(suppl_2), S97 (2005); https://doi.org/10.2337/diabetes.54.suppl_2.S97
  43. S. Tyagi, S. Sharma, P. Gupta, A.S. Saini and C. Kaushal, J. Adv. Pharm. Technol. Res., 2, 236 (2011); https://doi.org/10.4103/2231-4040.90879
  44. M. Furuhashi and G.S. Hotamisligil, Nat. Rev. Drug Discov., 7, 489 (2008); https://doi.org/10.1038/nrd2589
  45. P.C.H. Hollman, J.H.M. de Vries, S.D. van Leeuwen, M.J.B. Mengelers and M.B. Katan, Am. J. Clin. Nutr., 62, 1276 (1995); https://doi.org/10.1093/ajcn/62.6.1276
  46. H. Alinezhad, A. Azimi, M. Zare, M.A. Ebrahimzadeh, S. Eslami, S.F. Nabavi and S.M. Nabavi, Int. J. Food Prop., 16, 1169 (2013); https://doi.org/10.1080/10942912.2011.578319
  47. L.K. Stewart, Z. Wang, D. Ribnicky, J.L. Soileau, W.T. Cefalu and T.W. Gettys, Diabetologia, 52, 514 (2009); https://doi.org/10.1007/s00125-008-1252-0
  48. O. Kwon, P. Eck, S. Chen, C.P. Corpe, J.H. Lee, M. Kruhlak and M. Levine, FASEB J., 21, 366 (2007); https://doi.org/10.1096/fj.06-6620com
  49. O. Coskun, M. Kanter, A. Korkmaz and S. Oter, Pharmacol. Res., 51, 117 (2005); https://doi.org/10.1016/j.phrs.2004.06.002
  50. H.M. Eid, L.C. Martineau, A. Saleem, A. Muhammad, D. Vallerand, A. Benhaddou-Andaloussi, L. Nistor, A. Afshar, J.T. Arnason and P.S. Haddad, Mol. Nutr. Food Res., 54, 991 (2010); https://doi.org/10.1002/mnfr.200900218
  51. M.M. Alam, D. Meerza and I. Naseem, Life Sci., 109, 8 (2014); https://doi.org/10.1016/j.lfs.2014.06.005
  52. M. Kobori, S. Masumoto, Y. Akimoto and Y. Takahashi, Mol. Nutr. Food Res., 53, 859 (2009); https://doi.org/10.1002/mnfr.200800310
  53. S. Kreft, M. Knapp and I. Kreft, J. Agric. Food Chem., 47, 4649 (1999); https://doi.org/10.1021/jf990186p
  54. W.Y. Huang, H.C. Zhang, W.X. Liu and C.Y. Li, J. Zhejiang Univ. Sci. B, 13, 94 (2012); https://doi.org/10.1631/jzus.B1100137
  55. A. Ghorbani, Biomed. Pharmacother., 96, 305 (2017); https://doi.org/10.1016/j.biopha.2017.10.001
  56. P.S.M. Prince and N. Kamalakkannan, J. Biochem. Mol. Toxicol., 20, 96 (2006); https://doi.org/10.1002/jbt.20117
  57. V.D. Kappel, L.H. Cazarolli, D.F. Pereira, B.G. Postal, A. Zamoner, F.H. Reginatto and F.R.M.B. Silva, J. Pharm. Pharmacol., 65, 1179 (2013); https://doi.org/10.1111/jphp.12066
  58. N.T. Niture, A.A. Ansari and S.R. Naik, Indian J. Exp. Biol., 52, 720 (2014).
  59. Y.B. Wang, Z.M. Ge, W.Q. Kang, Z.X. Lian, J. Yao and C.Y. Zhou, Exp. Ther. Med., 9, 451 (2015); https://doi.org/10.3892/etm.2014.2090
  60. M.S. Ola, M.M. Ahmed, R. Ahmad, H.M. Abuohashish, S.S. Al-Rejaie and A.S. Alhomida, J. Mol. Neurosci., 56, 440 (2015); https://doi.org/10.1007/s12031-015-0561-2
  61. Y. Arai, S. Watanabe, M. Kimira, K. Shimoi, R. Mochizuki and N. Kinae, J. Nutr., 130, 2243 (2000); https://doi.org/10.1093/jn/130.9.2243
  62. P. Maher, R. Dargusch, J.L. Ehren, S. Okada, K. Sharma and D. Schubert, PLoS One, 6, e21226 (2011); https://doi.org/10.1371/journal.pone.0021226
  63. H.J. Kim, S.H. Kim and J.M. Yun, Evid. Based Complement. Alternat. Med., 2012, 639469 (2012); https://doi.org/10.1155/2012/639469
  64. G.S. Prasath and S.P. Subramanian, Eur. J. Pharmacol., 668, 492 (2011); https://doi.org/10.1016/j.ejphar.2011.07.021
  65. R.P. Constantin, J. Constantin, C.L.S. Pagadigorria, E.L. Ishii-Iwamoto, A. Bracht, M.K.C. Ono and N.S. Yamamoto, Cell Biochem. Funct., 28, 149 (2010); https://doi.org/10.1002/cbf.1635
  66. J. Ren, Y. Lu, Y. Qian, B. Chen, T. Wu and G. Ji, Exp. Ther. Med., 18, 2759 (2019); https://doi.org/10.3892/etm.2019.7886
  67. G. An, J. Gallegos and M.E. Morris, Drug Metab. Dispos., 39, 426 (2011); https://doi.org/10.1124/dmd.110.035212
  68. S.H. Hakkinen, S.O. Karenlampi, I.M. Heinonen, H.M. Mykkanen and A.R. Torronen, J. Agric. Food Chem., 47, 2274 (1999); https://doi.org/10.1021/jf9811065
  69. P. Nirmala and M. Ramanathan, Eur. J. Pharmacol., 654, 75 (2011); https://doi.org/10.1016/j.ejphar.2010.11.034
  70. A.P. Jorge, H. Horst, E. Sousa, M.G. Pizzolatti and F.R.M.B. Silva, Chem. Biol. Interact., 149, 89 (2004); https://doi.org/10.1016/j.cbi.2004.07.001
  71. Y. Zhang and D. Liu, Eur. J. Pharmacol., 670, 325 (2011); https://doi.org/10.1016/j.ejphar.2011.08.011
  72. D. Sharma, P. Gondaliya, V. Tiwari and K. Kalia, Biomed. Pharmacother., 109, 1610 (2019); https://doi.org/10.1016/j.biopha.2018.10.195
  73. L.M. Hung, J.K. Chen, S.S. Huang, R.S. Lee and M.J. Su, Cardiovasc. Res., 47, 549 (2000); https://doi.org/10.1016/S0008-6363(00)00102-4
  74. M.J. Atten, E. Godoy-Romero, B.M. Attar, T. Milson, M. Zopel and O. Holian, Invest. New Drugs, 23, 111 (2005); https://doi.org/10.1007/s10637-005-5855-8
  75. F.Z. Kalai, M. Boulaaba, F. Ferdousi and H. Isoda, Int. J. Mol. Sci., 23, 704 (2022); https://doi.org/10.3390/ijms23020704
  76. T. Yokozawa, H.Y. Kim, E.J. Cho, J.S. Choi and H.Y. Chung, J. Agric. Food Chem., 50, 5490 (2002); https://doi.org/10.1021/jf0202133
  77. R. Vinayagam and B. Xu, Nutr. Metab., 12, 60 (2015); https://doi.org/10.1186/s12986-015-0057-7
  78. Y.S. Lee, S. Lee, H.S. Lee, B.K. Kim, K. Ohuchi and K.H. Shin, Biol. Pharm. Bull., 28, 916 (2005); https://doi.org/10.1248/bpb.28.916
  79. K.F.S. Ricardo, T.T. Oliveira, T.J. Nagem, A.S. Pinto, M.G.A. Oliveira and J.F. Soares, Braz. Arch. Biol. Technol., 44, 263 (2001); https://doi.org/10.1590/S1516-89132001000300007
  80. V. Sreedharan, K.K. Venkatachalam and N. Namasivayam, Invest. New Drugs, 27, 21 (2009); https://doi.org/10.1007/s10637-008-9136-1
  81. V. Sendrayaperumal, S. Iyyam Pillai and S. Subramanian, Chem. Biol. Interact., 219, 9 (2014); https://doi.org/10.1016/j.cbi.2014.05.003
  82. P. Vanitha, N. Suganya, E. Bhakkiyalakshmi, S. Suriyanarayanan, P. Gunasekaran, C. Uma, S. Sivasubramanian and K.M. Ramkumar, Environ. Toxicol. Pharmacol., 37, 326 (2014); https://doi.org/10.1016/j.etap.2013.11.017
  83. Y.O. Kim, K. Leem, J. Park, P. Lee, D.K. Ahn, B.C. Lee, H.K. Park, K. Suk, S.Y. Kim and H. Kim, J. Ethnopharmacol., 77, 183 (2001); https://doi.org/10.1016/S0378-8741(01)00283-5
  84. P.A. Lapchak, P. Maher, D. Schubert and J.A. Zivin, Neuroscience, 150, 585 (2007); https://doi.org/10.1016/j.neuroscience.2007.09.033
  85. Y. Fu, J. Luo, Z. Jia, W. Zhen, K. Zhou, E. Gilbert and D. Liu, Int. J. Endocrinol., 2014, 846742 (2014); https://doi.org/10.1155/2014/846742
  86. A. Ahad, M. Mujeeb, H. Ahsan and W.A. Siddiqui, Biochimie, 106, 101 (2014); https://doi.org/10.1016/j.biochi.2014.08.006
  87. H.M. El-Bassossy, N.A. Hassan, M.F. Mahmoud and A. Fahmy, Phytomedicine, 21, 1742 (2014); https://doi.org/10.1016/j.phymed.2014.08.012
  88. P. Pu, X.-A. Wang, M. Salim, L.-H. Zhu, L. Wang, J. Chen, J.-F. Xiao, W. Deng, H.-W. Shi, H. Jiang and H.-L. Li, Mol. Cell. Endocrinol., 362, 128 (2012); https://doi.org/10.1016/j.mce.2012.06.002
  89. M.L. Neuhouser, Nutr. Cancer, 50, 1 (2004); https://doi.org/10.1207/s15327914nc5001_1
  90. K.H. Miean and S. Mohamed, J. Agric. Food Chem., 49, 3106 (2001); https://doi.org/10.1021/jf000892m
  91. L. Ding, D. Jin and X. Chen, J. Nutr. Biochem., 21, 941 (2010); https://doi.org/10.1016/j.jnutbio.2009.07.009
  92. Y. Zang, K. Igarashi and Y. Li, Biosci. Biotechnol. Biochem., 80, 1580 (2016); https://doi.org/10.1080/09168451.2015.1116928
  93. Y. Baek, M.N. Lee, D. Wu and M. Pae, Curr. Dev. Nutr., 13, FS12 (2019); https://doi.org/10.1093/cdn/nzz049.FS12-01-19
  94. M.A. Campanero, M. Escolar, G. Perez, E. Garcia-Quetglas, B. Sadaba and J.R. Azanza, J. Pharm. Biomed. Anal., 51, 875 (2010); https://doi.org/10.1016/j.jpba.2009.09.012
  95. Y. Manuel, B. Keenoy, J. Vertommen and I. De Leeuw, Diabetes Nutr. Metab., 12, 256 (1999).
  96. L. Pari and S. Srinivasan, Biomed. Pharmacother., 64, 477 (2010); https://doi.org/10.1016/j.biopha.2010.02.001
  97. S. Srinivasan and L. Pari, J. Funct. Foods, 5, 484 (2013); https://doi.org/10.1016/j.jff.2012.12.004
  98. J.A. Ross and C.M. Kasum, Annu. Rev. Nutr., 22, 19 (2002); https://doi.org/10.1146/annurev.nutr.22.111401.144957
  99. S. Panda and A. Kar, J. Pharm. Pharmacol., 59, 1543 (2010); https://doi.org/10.1211/jpp.59.11.0012
  100. A.A. Mrazek, L.J. Porro, V. Bhatia, M. Falzon, H. Spratt, J. Zhou, C. Chao and M.R. Hellmich, J. Surg. Res., 196, 8 (2015); https://doi.org/10.1016/j.jss.2015.02.032
  101. C.M. Hossain, M.K. Ghosh, B.S. Satapathy, N.S. Dey and B. Mukherjee, Am. J. Pharmacol. Toxicol., 9, 39 (2014); https://doi.org/10.3844/ajptsp.2014.39.52
  102. N. Wang, W.J. Yi, L. Tan, J.H. Zhang, J. Xu, Y. Chen, M. Qin, S. Yu, J. Guan and R. Zhang, In Vitro Cell. Dev. Biol. Anim., 53, 554 (2017); https://doi.org/10.1007/s11626-017-0135-4
  103. S. Malik, K. Suchal, S.I. Khan, J. Bhatia, K. Kishore, A.K. Dinda and D.S. Arya, Am. J. Physiol. Renal Physiol., 313, F414 (2017); https://doi.org/10.1152/ajprenal.00393.2016
  104. M.S. Kim, H.J. Hur, D.Y. Kwon and J.T. Hwang, Mol. Cell. Endocrinol., 358, 127 (2012); https://doi.org/10.1016/j.mce.2012.03.013
  105. R. Sundaram, P. Shanthi and P. Sachdanandam, Phytomedicine, 21, 793 (2014); https://doi.org/10.1016/j.phymed.2014.01.007
  106. Y. Miyata, H. Tanaka, A. Shimada, T. Sato, A. Ito, T. Yamanouchi and H. Kosano, Life Sci., 88, 613 (2011); https://doi.org/10.1016/j.lfs.2011.01.024
  107. Y. Liu, J. Han, Z. Zhou and D. Li, J. Cell. Biochem., 120, 3286 (2019); https://doi.org/10.1002/jcb.27596
  108. M.C. Tai, S.Y. Tsang, L.Y. Chang and H. Xue, CNS Drug Rev., 11, 141 (2005); https://doi.org/10.1111/j.1527-3458.2005.tb00266.x
  109. E.J. Bak, J. Kim, Y.H. Choi, J.H. Kim, D.E. Lee, G.H. Woo, J.-H. Cha and Y.-J. Yoo, Clin. Nutr., 33, 156 (2014); https://doi.org/10.1016/j.clnu.2013.03.013
  110. W.J. Sandborn and W.A. Faubion, Curr. Gastroenterol. Rep., 2, 440 (2000); https://doi.org/10.1007/s11894-000-0005-0
  111. S.K. Ku and J.S. Bae, BMB Rep., 48, 519 (2015); https://doi.org/10.5483/BMBRep.2015.48.9.017
  112. S. Khan, D. Zhang, Y. Zhang, M. Li and C. Wang, Mol. Cell. Endocrinol., 428, 101 (2016); https://doi.org/10.1016/j.mce.2016.03.025
  113. C.A. Williams, J.B. Harborne, M. Newman, J. Greenham and J. Eagles, Phytochemistry, 46, 1349 (1997); https://doi.org/10.1016/S0031-9422(97)00514-1
  114. A. Ahad, A.A. Ganai, M. Mujeeb and W.A. Siddiqui, Toxicol. Appl. Pharmacol., 279, 1 (2014); https://doi.org/10.1016/j.taap.2014.05.007
  115. S. Samarghandian, M. Azimi-Nezhad, F. Samini and T. Farkhondeh, Can. J. Physiol. Pharmacol., 94, 388 (2016); https://doi.org/10.1139/cjpp-2014-0412
  116. R. Li, A. Zang, L. Zhang, H. Zhang, L. Zhao, Z. Qi and H. Wang, Neurol. Sci., 35, 1527 (2014); https://doi.org/10.1007/s10072-014-1784-7
  117. D. Sirovina, N. Orsolic, M.Z. Koncic, G. Kovacevic, V. Benkovic and G. Gregorovic, Hum. Exp. Toxicol., 32, 1058 (2013); https://doi.org/10.1177/0960327112472993
  118. H.M. El-Bassossy, S.M. Abo-Warda and A. Fahmy, Phytother. Res., 27, 1678 (2013); https://doi.org/10.1002/ptr.4917
  119. J.A. Emim, A.B. Oliveira and A.J. Lapa, J. Pharm. Pharmacol., 46, 118 (2011); https://doi.org/10.1111/j.2042-7158.1994.tb03753.x
  120. K. Kawaguchi, T. Mizuno, K. Aida and K. Uchino, Biosci. Biotechnol. Biochem., 61, 102 (1997); https://doi.org/10.1271/bbb.61.102
  121. A. Visnagri, A.D. Kandhare, S. Chakravarty, P. Ghosh and S.L. Bodhankar, Pharm. Biol., 52, 814 (2014); https://doi.org/10.3109/13880209.2013.870584
  122. A. Gumieniczek, Life Sci., 74, 553 (2003); https://doi.org/10.1016/j.lfs.2003.03.004
  123. X. Shi, S. Liao, H. Mi, C. Guo, D. Qi, F. Li, C. Zhang and Z. Yang, Molecules, 17, 12868 (2012); https://doi.org/10.3390/molecules171112868
  124. Y.O. Agrawal, P.K. Sharma, B. Shrivastava, S. Ojha, H.M. Upadhya, D.S. Arya and S.N. Goyal, PLoS One, 9, e111212 (2014); https://doi.org/10.1371/journal.pone.0111212
  125. S. Akiyama, S. Katsumata, K. Suzuki, Y. Ishimi, J. Wu and M. Uehara, J. Clin. Biochem. Nutr., 46, 87 (2009); https://doi.org/10.3164/jcbn.09-82
  126. S. Akiyama, S. Katsumata, K. Suzuki, Y. Nakaya, Y. Ishimi and M. Uehara, Biosci. Biotechnol. Biochem., 73, 2779 (2009); https://doi.org/10.1271/bbb.90576
  127. E. Dokumacioglu, H. Iskender and A. Musmul, Biomed. Pharmacother., 109, 1206 (2019); https://doi.org/10.1016/j.biopha.2018.10.192
  128. L.J. Wilcox, N.M. Borradaile and M.W. Huff, Cardiovasc. Drug Rev., 17, 160 (1999); https://doi.org/10.1111/j.1527-3466.1999.tb00011.x
  129. F.A. Van Acker, O. Schouten, G.R. Haenen, W.J. van der Vijgh and A. Bast, FEBS Lett., 473, 145 (2000); https://doi.org/10.1016/S0014-5793(00)01517-9
  130. J.C. Sanchez-Salgado, R.R. Ortiz-Andrade, F. Aguirre-Crespo, J. Vergara-Galicia, I. Leon-Rivera, S. Montes, R. Villalobos-Molina and S. Estrada-Soto, J. Ethnopharmacol., 109, 400 (2007); https://doi.org/10.1016/j.jep.2006.08.008
  131. D.H. Priscilla, D. Roy, A. Suresh, V. Kumar and K. Thirumurugan, Chem. Biol. Interact., 210, 77 (2014); https://doi.org/10.1016/j.cbi.2013.12.014
  132. S. Kannappan and C.V. Anuradha, Eur. J. Nutr., 49, 101 (2010); https://doi.org/10.1007/s00394-009-0054-6
  133. E.E. Mulvihill, E.M. Allister, B.G. Sutherland, D.E. Telford, C.G. Sawyez, J.Y. Edwards, J.M. Markle, R.A. Hegele and M.W. Huff, Diabetes, 58, 2198 (2009); https://doi.org/10.2337/db09-0634
  134. D. Rath, B. Kar and G. Pattnaik, Plant Arch., 20, 7806 (2020).
  135. D. Rath, G. Pattnaik and B. Kar, Asian J. Chem., 33, 2589 (2021); https://doi.org/10.14233/ajchem.2021.23389
  136. T. Annadurai, A.R. Muralidharan, T. Joseph, M.J. Hsu, P.A. Thomas and P. Geraldine, J. Physiol. Biochem., 68, 307 (2012); https://doi.org/10.1007/s13105-011-0142-y
  137. D.I. Al-Dosari, M.M. Ahmed, S.S. Al-Rejaie, A.S. Alhomida and M.S. Ola, Nutrients, 9, 1161 (2017); https://doi.org/10.3390/nu9101161
  138. W.-Y. Zhang, J.-J. Lee, Y. Kim, I.-S. Kim, J.-H. Han, S.-G. Lee, M.-J. Ahn, S.-H. Jung and C.-S. Myung, J. Agric. Food Chem., 60, 7652 (2012); https://doi.org/10.1021/jf300601z
  139. A. Hameed, R.M. Hafizur, N. Hussain, S.A. Raza, M. Rehman, S. Ashraf, Z. Ul-Haq, F. Khan, G. Abbas and M.I. Choudhary, Eur. J. Pharmacol., 820, 245 (2018); https://doi.org/10.1016/j.ejphar.2017.12.015
  140. Y. Miyake, K. Yamamoto, N. Tsujihara and T. Osawa, Lipids, 33, 689 (1998); https://doi.org/10.1007/s11745-998-0258-y
  141. C. Bucolo, G.M. Leggio, F. Drago and S. Salomone, Biochem. Pharmacol., 84, 88 (2012); https://doi.org/10.1016/j.bcp.2012.03.019
  142. H.B. Patisaul and W. Jefferson, Front. Neuroendocrinol., 31, 400 (2010); https://doi.org/10.1016/j.yfrne.2010.03.003
  143. T.L. Guo, Y. Wang, T. Xiong, X. Ling and J. Zheng, Toxicol. Appl. Pharmacol., 280, 455 (2014); https://doi.org/10.1016/j.taap.2014.08.028
  144. P.V. Babu, H. Si, Z. Fu, W. Zhen and D. Liu, J. Nutr., 142, 724 (2012); https://doi.org/10.3945/jn.111.152322
  145. N. Palanisamy, P. Viswanathan and C.V. Anuradha, Ren. Fail., 30, 645 (2008); https://doi.org/10.1080/08860220802134532
  146. A.A. Elmarakby, A.S. Ibrahim, J. Faulkner, M.S. Mozaffari, G.I. Liou and R. Abdelsayed, Vascul. Pharmacol., 55, 149 (2011); https://doi.org/10.1016/j.vph.2011.07.007
  147. Z. Fu, E.R. Gilbert, L. Pfeiffer, Y. Zhang, Y. Fu and D. Liu, Appl. Physiol. Nutr. Metab., 37, 480 (2012); https://doi.org/10.1139/h2012-005
  148. A.E. Valsecchi, S. Franchi, A.E. Panerai, A. Rossi, P. Sacerdote and M. Colleoni, Eur. J. Pharmacol., 650, 694 (2011); https://doi.org/10.1016/j.ejphar.2010.10.060
  149. L. Zhou, X. Xiao, Q. Zhang, J. Zheng, M. Li, M. Yu, X. Wang, M. Deng, X. Zhai, R. Li and and J. Liu, Int. J. Endocrinol., 17, 2163838 (2019); https://doi.org/10.1155/2019/2163838
  150. J. Liggins, L.J. Bluck, S. Runswick, C. Atkinson, W.A. Coward and S.A. Bingham, J. Nutr. Biochem., 11, 326 (2000); https://doi.org/10.1016/S0955-2863(00)00085-1
  151. D. Rath, P. Bhukta, K. Sethy, B.B. Sahu, C.S. Patro, G. Pattanik and B. Kar, J. Pharm. Negat. Results, 13(S8), 3530 (2022).
  152. S. Kapiotis, B. Jilma, Y. Szalay, E. Dirnberger, O. Wagner, H.-G. Eichler and W. Speiser, Arterioscler. Thromb. Vasc. Biol., 17, 2861 (1997); https://doi.org/10.1161/01.ATV.17.11.2861
  153. S.A. Park, M.-S. Choi, S.-Y. Cho, J.-S. Seo, U.J. Jung, M.-J. Kim, M.-K. Sung, Y.B. Park and M.-K. Lee, Life Sci., 79, 1207 (2006); https://doi.org/10.1016/j.lfs.2006.03.022
  154. C.R. Cederroth, M. Vinciguerra, A. Gjinovci, F. Kuhne, M. Klein, M. Cederroth, D. Caille, M. Suter, D. Neumann, R.W. James, D.R. Doerge, T. Wallimann, P. Meda, M. Foti, F. Rohner-Jeanrenaud, J.-D. Vassalli and S. Nef, Diabetes, 57, 1176 (2008); https://doi.org/10.2337/db07-0630
  155. S.H. Cheong, K. Furuhashi, K. Ito, M. Nagaoka, T. Yonezawa, Y. Miura and K. Yagasaki, J. Nutr. Biochem., 25, 136 (2014); https://doi.org/10.1016/j.jnutbio.2013.09.012
  156. D. Das, S. Sarkar, J. Bordoloi, S.B. Wann, J. Kalita and P. Manna, Biofactors, 44, 407 (2018); https://doi.org/10.1002/biof.1439
  157. T. Song, S.O. Lee, P.A. Murphy and S. Hendrich, Exp. Biol. Med., 228, 1063 (2003); https://doi.org/10.1177/153537020322800912
  158. S. Akkarachiyasit, P. Charoenlertkul, S. Yibchok-Anun and S. Adisakwattana, Int. J. Mol. Sci., 11, 3387 (2010); https://doi.org/10.3390/ijms11093387
  159. I.T. Nizamutdinova, Y.C. Jin, J.I. Chung, S.C. Shin, S.J. Lee, H.G. Seo, J.H. Lee, K.C. Chang and H.J. Kim, Mol. Nutr. Food Res., 53, 1419 (2009); https://doi.org/10.1002/mnfr.200800526
  160. S. Nasri, M. Roghani, T. Baluchnejadmojarad, T. Rabani and M. Balvardi, Pathophysiology, 18, 273 (2011); https://doi.org/10.1016/j.pathophys.2011.03.001
  161. W. Zhu, Q. Jia, Y. Wang, Y. Zhang and M. Xia, Free Radic. Biol. Med., 52, 314 (2012); https://doi.org/10.1016/j.freeradbiomed.2011.10.483
  162. X. Jiang, X. Tang, P. Zhang, G. Liu and H. Guo, Biochem. Pharmacol., 90, 135 (2014); https://doi.org/10.1016/j.bcp.2014.04.018
  163. S. Bertuglia, S. Malandrino and A. Colantuoni, Arzneimittelforschung, 45, 481 (1995).
  164. A. Gharib, Z. Faezizadeh and M. Godarzee, Planta Med., 79, 1599 (2013); https://doi.org/10.1055/s-0033-1350908
  165. E. Daveri, E. Cremonini, A. Mastaloudis, S.N. Hester, S.M. Wood, A.L. Waterhouse, M. Anderson, C.G. Fraga and P.I. Oteiza, Redox Biol., 18, 16 (2018); https://doi.org/10.1016/j.redox.2018.05.012
  166. J. Hidalgo, S. Teuber, F.J. Morera, C. Ojeda, C.A. Flores, M.A. Hidalgo, L. Núñez, C. Villalobos and R.A. Burgos, Int. J. Mol. Sci., 18, 750 (2017); https://doi.org/10.3390/ijms18040750
  167. G. Mazza, Int. J. Fruit Sci., 5, 101 (2005); https://doi.org/10.1300/J492v05n03_10
  168. M. Roy, S. Sen and A.S. Chakraborti, Life Sci., 82, 1102 (2008); https://doi.org/10.1016/j.lfs.2008.03.011
  169. M. Mirshekar, M. Roghani, M. Khalili, T. Baluchnejadmojarad and M.S. Arab, Iran. Biomed. J., 14, 33 (2010).
  170. B. Jayaprakasam, S.K. Vareed, L.K. Olson and M.G. Nair, J. Agric. Food Chem., 53, 28 (2005); https://doi.org/10.1021/jf049018+
Read More
Author biographies is not available.
Statistic
Read Counter : 2 Download : 10