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Vol. 35 No. 9 (2023): Vol 35 Issue 9, 2023

Copyright (c) 2023 deepankar rath, BISWAKANTH KAR, GURUDUTTA PATTNAIK, pallishree bhukta

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Flavonoids and their Role in the Remedy of Diabetes Mellitus: A Review

https://doi.org/10.14233/ajchem.2023.28082
Deepankar Rath
Department of Pharmacology, School of Pharmacy and Life Sciences, Centurion University of Technology and Management, Ramchandrapur, P.O. Jatni, Bhubaneswar-752050, India
https://orcid.org/0000-0001-9879-2605
Biswakanth Kar
Department of Pharmacology, School of Pharmaceutical Sciences, Siksha O Anusandhan University, Bhubaneswar-751030, Odisha, India, Email id-biswa_kanth2005@yahoo.co.in
https://orcid.org/0000-0002-4530-1005
Gurudutta Pattnaik
Department of Pharmaceutics, School of Pharmacy and Life Sciences, Centurion University of Technology and Management, Odisha, India-752050
https://orcid.org/0000-0002-3532-721X
Pallishree Bhukta
Department of Pharmacology, School of Pharmacy and Life Sciences, Centurion University of Technology and Management, Odisha, India-752050
https://orcid.org/0000-0002-5826-9569

Corresponding Author(s) : Biswakanth Kar

biswa_kanth2005@yahoo.co.in

Asian Journal of Chemistry, Vol. 35 No. 9 (2023): Vol 35 Issue 9, 2023

Abstract

The impact of diabetes mellitus on the health care system is significant due to its global prevalence affecting millions of individuals. This condition is commonly related with factors such as obesity, urbanization, and genetic alterations. Those with diabetes mellitus have elevated blood glucose levels because an inability to produce, secrete or bind to insulin causes a lowering of insulin levels. Flavonoids are phenolic compounds found in fruits, vegetables and fungi. Carbon atoms are comprised of 15 chains of three carbon atoms in a skeleton. The anthocyanidin family includes flavonoids, flavones, flavanones, isoflavones, flavanols and flavonoids. In addition to their antidiabetic properties, flavonoids also have antioxidant properties. Molecular mechanisms underlying the antidiabetic properties of dietary flavonoids are summarized in this review. Other natural compounds with antidiabetic properties include cosmosiin, didymin, diosmin, naringin, isosiennsetin, nobiletin, poncirin, quercetin, rhoifolin, sinensetin, naringenin, sudachitin, rutin, hesperidin and tangeretin, which also improve lipid and phospholipid metabolism. The progression of diabetes is influenced by diabetes biomarkers. Citrus flavonoids are therefore promising candidates for antidiabetic action, even though further research is necessary to prove their effectiveness.

Keywords

Diabetes mellitus Flavonoids hyperglycaemia Antidiabetic Glycaemic control
Rath, D., Kar, B., Pattnaik, G., & Bhukta, P. (2023). Flavonoids and their Role in the Remedy of Diabetes Mellitus: A Review. Asian Journal of Chemistry, 35(9), 2021–2030. https://doi.org/10.14233/ajchem.2023.28082
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