Synthesis of Aryl Urea Derivatives from Aryl Amines and Aryl Isocyanates
Corresponding Author(s) : V. Usharani
uvattikuti@yahoo.co.in
Asian Journal of Chemistry,
Vol. 23 No. 4 (2011): Vol 23 Issue 4
Abstract
The present study describes the synthesis of novel diaryl urea derivatives derived from aryl amine and aryl isocyanates. The synthesized compounds are analogs of sorafenib [4-[4-[[[4- chloro-3-(trifluoromethyl)phenyl]amino]carbonyl]amino]phenoxy]-N-methylpyridine-2- carboxamide] having potential antiproliferative activity.
Keywords
Sorafenib
Kinase inhibitor
Triphosgene
Aryl isocyanates
Diaryl ureas
Usharani, V., Bhujanga Rao, A., Pulla Reddy, M., & Dubey, P. (2010). Synthesis of Aryl Urea Derivatives from Aryl Amines and Aryl Isocyanates. Asian Journal of Chemistry, 23(4), 1802–1806. Retrieved from https://asianpubs.org/index.php/ajchem/article/view/10212
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