Isolation and Toxicity of Steroidal Alkaloid Glycoside from Fruits of Ranti Hitam (Solanum blumei Nees ex Blume)

Murniaty Simorangkir; Tonel Barus; Ribu Surbakti; Partomuan Simanjuntak

doi:10.14233/ajchem.2016.19345

Issue

Vol. 28 No. 1 (2016): Vol 28 Issue 1

Issue Published : October 5, 2015

This work is licensed under a Creative Commons Attribution 4.0 International License.

Isolation and Toxicity of Steroidal Alkaloid Glycoside from Fruits of Ranti Hitam (Solanum blumei Nees ex Blume)

https://doi.org/10.14233/ajchem.2016.19345

Murniaty Simorangkir

Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Negeri Medan, Jalan Willem Iskandar, Medan, Indonesia; Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Sumatera Utara, Jalan Padang Bulan, Medan, Indonesia

Tonel Barus

Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Sumatera Utara, Jalan Padang Bulan, Medan, Indonesia

Ribu Surbakti

Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Sumatera Utara, Jalan Padang Bulan, Medan, Indonesia

Partomuan Simanjuntak

Research Centre of Biotechnology, Indonesian Institute of Sciences (LIPI), Cibinong, Indonesia; Faculty of Pharmacy, Universitas Pancasila, Srengseng Sawah Jagakarsa, Jakarta, Indonesia

Corresponding Author(s) : Murniaty Simorangkir

murni_simor2011@yahoo.co.id

Asian Journal of Chemistry, Vol. 28 No. 1 (2016): Vol 28 Issue 1
Article Published : October 6, 2015

Abstract

One steroidal alkaloid glycoside compound as b2-solanin or solanid-5-ene-(1’®3)-b-D-galactopyranosyl-(1”®3)-b-D-glucopyranoside has been isolated from the fruits of an Indonesian medicinal plant, Solanum blumei Nees ex Blume (Solanaceae). The structure of the compound was identified by using spectral data analysis viz., ultraviolet, infrared, 1D NMR (¹H-, ¹³C- and DEPT), 2D NMR (COSY, HMQC and HMBC) and mass spectra. The compound has toxicity with LC₅₀ value 17.97 μg/mL by Brine Shrimp Lethality Test (BSLT) method. The compound considered as highly toxic because it has LC₅₀ < 30 μg/mL.

Keywords

b2-Solanine Glycoalkaloid Solanum blumei Nees ex Blume Indonesian medicinal plant

Simorangkir, M., Barus, T., Surbakti, R., & Simanjuntak, P. (2015). Isolation and Toxicity of Steroidal Alkaloid Glycoside from Fruits of Ranti Hitam (Solanum blumei Nees ex Blume). Asian Journal of Chemistry, 28(1), 203–206. https://doi.org/10.14233/ajchem.2016.19345

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References

M. Simorangkir, R. Surbakti, T. Barus and P. Simanjuntak, Proceeding of National Seminar on Chemistry: Sumatera Utara University, ISBN: 979-458-692-7, pp. 303-311 (2013) (in Indonesian).
J.B. Harborne, Phytochemical Methods, A Guide to Modern Methods of Plants Analysis, Chapman & Hall, New York, pp. 7-43 (1973).
B. Meyer, N. Ferrigni, J. Putnam, L. Jacobsen, D. Nichols and J. McLaughlin, Planta Med., 45, 31 (1982); doi:10.1055/s-2007-971236.
M. Simorangkir, R. Surbakti, T. Barus and P. Simanjuntak, Proceeding of National Seminar on Chemistry, Post Graduated of Sumatera Utara University, ISBN: 979-458-746, pp. 226-229 (2014) (in Indonesian).
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D.R. Lawson, T.P. Green, L.W. Haynes and A.R. Miller, J. Agric. Food Chem., 45, 4122 (1997); doi:10.1021/jf9702914.
A. Mohy-Ud-Din, K. Zaheer-Ud-Din, M. Ahmad and M.A. Kashmiri, Pak. J. Bot., 42, 653 (2010).
M. Steven and R. Molyneux, Bioactive Natural Products, CRC Press Boca Raton Ann Arbor, London, Tokyo, pp. 3-14 (1993).
R.M. Silverstein, F. Webster and D. Kiemle, Spectrometric Identification of Organic Compounds, John Wiley & Son Inc., New York, edn 7, pp. 5/267-5/270 (2005).
E.A. Eltayeb, A.S. Al-Ansari and J.G. Roddick, Phytochemistry, 46, 489 (1997); doi:10.1016/S0031-9422(97)00323-3.
T. Ikeda, H. Tsumagari and T. Nohara, Chem. Pharm. Bull. (Tokyo), 48, 1062 (2000); doi:10.1248/cpb.48.1062.
K. Hu, H. Kobayashi, A. Dong, Y. Jing, S. Iwasaki and X. Yao, Planta Med., 65, 35 (1999); doi:10.1055/s-1999-13958.
R. Kartika, T. Barus, R. Surbakti and P. Simanjuntak, Asian J. Chem., 26, 6047 (2014); doi:10.14233/ajchem.2014.16562.

References

M. Simorangkir, R. Surbakti, T. Barus and P. Simanjuntak, Proceeding of National Seminar on Chemistry: Sumatera Utara University, ISBN: 979-458-692-7, pp. 303-311 (2013) (in Indonesian).

J.B. Harborne, Phytochemical Methods, A Guide to Modern Methods of Plants Analysis, Chapman & Hall, New York, pp. 7-43 (1973).

B. Meyer, N. Ferrigni, J. Putnam, L. Jacobsen, D. Nichols and J. McLaughlin, Planta Med., 45, 31 (1982); doi:10.1055/s-2007-971236.

M. Simorangkir, R. Surbakti, T. Barus and P. Simanjuntak, Proceeding of National Seminar on Chemistry, Post Graduated of Sumatera Utara University, ISBN: 979-458-746, pp. 226-229 (2014) (in Indonesian).

F.O. Atanu, U.G. Ebiloma, and E.I. Ajayi, Biotechnol. Mol. Biol. Rev., 6, 1 (2011).

M.M. Shabana, M.M. Salama, S.M. Ezzat and L.R. Ismail, J. Carcinogene Mutagene, 4, 149 (2013); doi:10.4172/2157-2518.1000149.

M.R. Cooper and A.W. Johnson, Poisonous Plants in Britain and other Effects on Animals and Man, Ministry of Agriculture, Fisheries Food, Ref. Book No. 161, pp. 219-220 (1984).

S.J. Lee and K.T. Lim, Toxicol. In Vitro, 20, 1088 (2006); doi:10.1016/j.tiv.2006.01.019.

D.R. Lawson, T.P. Green, L.W. Haynes and A.R. Miller, J. Agric. Food Chem., 45, 4122 (1997); doi:10.1021/jf9702914.

A. Mohy-Ud-Din, K. Zaheer-Ud-Din, M. Ahmad and M.A. Kashmiri, Pak. J. Bot., 42, 653 (2010).

M. Steven and R. Molyneux, Bioactive Natural Products, CRC Press Boca Raton Ann Arbor, London, Tokyo, pp. 3-14 (1993).

R.M. Silverstein, F. Webster and D. Kiemle, Spectrometric Identification of Organic Compounds, John Wiley & Son Inc., New York, edn 7, pp. 5/267-5/270 (2005).

E.A. Eltayeb, A.S. Al-Ansari and J.G. Roddick, Phytochemistry, 46, 489 (1997); doi:10.1016/S0031-9422(97)00323-3.

T. Ikeda, H. Tsumagari and T. Nohara, Chem. Pharm. Bull. (Tokyo), 48, 1062 (2000); doi:10.1248/cpb.48.1062.

K. Hu, H. Kobayashi, A. Dong, Y. Jing, S. Iwasaki and X. Yao, Planta Med., 65, 35 (1999); doi:10.1055/s-1999-13958.

R. Kartika, T. Barus, R. Surbakti and P. Simanjuntak, Asian J. Chem., 26, 6047 (2014); doi:10.14233/ajchem.2014.16562.

Issue

Vol. 28 No. 1 (2016): Vol 28 Issue 1

Isolation and Toxicity of Steroidal Alkaloid Glycoside from Fruits of Ranti Hitam (Solanum blumei Nees ex Blume)

Corresponding Author(s) : Murniaty Simorangkir

Abstract

Keywords

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