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Vol. 31 No. 2 (2019): Vol. 31 No. 2

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Green Synthesis Approaches of 2-Bromo-4-methyl thiazole-5-carboxamide Derivatives as Potent Microbial Agents

https://doi.org/10.14233/ajchem.2019.21571
Jeevanreddy Miryala
Department of Chemistry, Osmania University, Hyderabad-500007, India
Mahesh Morthad
Department of Chemistry, Osmania University, Hyderabad-500007, India
Satyanarayana Battu
Department of Chemistry, Osmania University, Hyderabad-500007, India

Corresponding Author(s) : Satyanarayana Battu

satyambchem@yahoo.co.in

Asian Journal of Chemistry, Vol. 31 No. 2 (2019): Vol. 31 No. 2

Abstract

As a part of our ongoing research in the development of new, selective and environmental friendly methodologies, herein we report a new series of 2-bromo-4-methylthiazole-5-carboxamide derivatives using polyethylene glycol-400 (PEG-400) as a solvent. All the newly synthesized compounds were screened to their in vitro antimicrobial activities and all the compounds exhibited remarkable growth inhibition of wide spectrum of Gram-positive bacteria and Gram-negative bacteria. Molecular docking was done performed computational software GOLD (Genetic algorithm based, flexible ligand, partial flexibility for protein).

Keywords

Thiazole PEG-400 Antimicrobial activity Docking
Miryala, J., Morthad, M., & Battu, S. (2018). Green Synthesis Approaches of 2-Bromo-4-methyl thiazole-5-carboxamide Derivatives as Potent Microbial Agents. Asian Journal of Chemistry, 31(2), 297–302. https://doi.org/10.14233/ajchem.2019.21571
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