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Vol. 31 No. 9 (2019): Vol 31 Issue 9

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Physico-Chemical Studies of Chitosan Derivatives and Optimization of Reaction Conditions using RSM Design

https://doi.org/10.14233/ajchem.2019.22095
Vandana Suryavanshi
Department of Chemistry, National Institute of Technology, Raipur-492010, India
Alekha Kumar Sutar
Catalysis Research Lab, Department of Chemistry, Ravenshaw University, Cuttack-753003, India
Tungabidya Maharana
Department of Chemistry, National Institute of Technology, Raipur-492010, India

Corresponding Author(s) : Tungabidya Maharana

tmaharana.chy@nitrr.ac.in

Asian Journal of Chemistry, Vol. 31 No. 9 (2019): Vol 31 Issue 9

Abstract

In this work, the chitosan flake was converted to carboxymethyl chitosan (CMCS) by carboxymethylation process using monochloroacetic acid in alkaline condition. The structure of carboxymethyl chitosan was confirmed by NMR, FT-IR, XRD, TGA and SEM techniques. The average molecular weight of carboxymethyl chitosan was obtained by viscometry method. The carboxymethylation reaction of chitosan was optimized for the reaction time, reaction temperature, amount of chitosan, amount of monochloroacetic acid. Response surface methodology (RSM) was used to analyze degree of substitution, degree of acetylation and yield with respect to reaction conditions. At the optimization reaction condition the degree of substitution, degree of acetylation (%) and yield (%) values are 0.56, 33.99 and 78.2, respectively.

Keywords

Chitosan Carboxymethylation Response surface methodology Degree of substitution Degree of acetylation
Suryavanshi, V., Sutar, A. K., & Maharana, T. (2019). Physico-Chemical Studies of Chitosan Derivatives and Optimization of Reaction Conditions using RSM Design. Asian Journal of Chemistry, 31(9), 2029–2036. https://doi.org/10.14233/ajchem.2019.22095
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